Accuracy and effectiveness of HPV mRNA testing in cervical cancer screening: a systematic review and meta-analysis

M Arbyn, M Simon, S de Sanjosé, MA Clarke… - The Lancet …, 2022 - thelancet.com
Background Cervical cancer screening tests that identify DNA of the main causal agent, high-
risk human papillomavirus (HPV) types, are more protective than cervical cytology. We …

[HTML][HTML] A review of the clinical performance of the Aptima HPV assay

J Haedicke, T Iftner - Journal of Clinical Virology, 2016 - Elsevier
This comprehensive review compiles published data from 62 original articles comparing
different HPV tests and one meta-analysis on the clinical performance of the Aptima HR HPV …

Meta‐analysis of the accuracy of p16 or p16/Ki‐67 immunocytochemistry versus HPV testing for the detection of CIN2+/CIN3+ in triage of women with minor abnormal …

E Peeters, N Wentzensen, C Bergeron… - Cancer …, 2019 - Wiley Online Library
Background Women with atypical squamous cells of undetermined significance (ASC‐US)
can be triaged accurately with a high‐risk human papillomavirus (hrHPV) test to identify …

[HTML][HTML] Performance of p16/Ki67 immunostaining, HPV E6/E7 mRNA testing, and HPV DNA assay to detect high-grade cervical dysplasia in women with ASCUS

Y Zhu, C Ren, L Yang, X Zhang, L Liu, Z Wang - BMC cancer, 2019 - Springer
Background Atypical squamous cell of undetermined significance (ASCUS) is a common
cervical cytological diagnosis. At present, HPV DNA assay is used to triage these patients …

ANOVA model for network meta-analysis of diagnostic test accuracy data

VN Nyaga, M Aerts, M Arbyn - Statistical methods in medical …, 2018 - journals.sagepub.com
Procedures combining and summarising direct and indirect evidence from independent
studies assessing the diagnostic accuracy of different tests for the same disease are referred …

Use of Cytology, E6/E7 mRNA, and p16INK4a–Ki-67 to Define the Management of Human Papillomavirus (HPV)–Positive Women in Cervical Cancer Screening

D Gustinucci, PG Rossi, E Cesarini… - American journal of …, 2016 - academic.oup.com
Objectives: We measured the accuracy of p16INK4a-Ki67 (CINtec PLUS, Roche, Mannheim,
Germany), and E6/E7mRNA (types 16/18/31/33/45 NucliSENS easyQ, bioMérieux, Boxtel …

An Intelligent Clinical Decision Support System for Patient‐Specific Predictions to Improve Cervical Intraepithelial Neoplasia Detection

P Bountris, M Haritou, A Pouliakis… - BioMed Research …, 2014 - Wiley Online Library
Nowadays, there are molecular biology techniques providing information related to cervical
cancer and its cause: the human Papillomavirus (HPV), including DNA microarrays …

[HTML][HTML] E6/E7 mRNA testing for human papilloma virus-induced high-grade cervical intraepithelial disease (CIN2/CIN3): a promising perspective

M Origoni, P Cristoforoni, G Carminati… - …, 2015 - ncbi.nlm.nih.gov
Since the introduction of biomolecular testing for the identification of high-risk human
papillomavirus DNA (hrHPV-DNA) in cervical cancer preventive strategies, many interesting …

HPV E6/E7 mRNA versus HPV DNA biomarker in cervical cancer screening of a group of Macedonian women

S Duvlis, K Popovska‐Jankovic… - Journal of medical …, 2015 - Wiley Online Library
High risk types of human papillomaviruses E6/E7 oncogenes and their association with
tumor suppressor genes products are the key factors of cervical carcinogenesis. This study …

p16INK4a and Ki67 expression in normal, dysplastic and neoplastic uterine cervical epithelium and human papillomavirus (HPV) infection

LN Calil, MIA Edelweiss, L Meurer, CN Igansi… - … -Research and Practice, 2014 - Elsevier
Cellular cycle proteins like the p16 INK4a and the Ki67 proliferation nuclear antigen have
been used as oncogenicity cellular markers. The E6 and E7 oncoproteins interact with tumor …