Obstructive sleep apnoea and cardiovascular consequences: pathophysiological mechanisms

C Arnaud, T Bochaton, JL Pépin, E Belaidi - Archives of cardiovascular …, 2020 - Elsevier
Obstructive sleep apnoea syndrome is a growing health concern, affecting nearly one billion
people worldwide; it is an independent cardiovascular risk factor, associated with incident …

Obstructive sleep apnea: a cardiometabolic risk in obesity and the metabolic syndrome

LF Drager, SM Togeiro, VY Polotsky… - Journal of the American …, 2013 - jacc.org
Obstructive sleep apnea (OSA) is an underdiagnosed condition characterized by recurrent
episodes of obstruction of the upper airway leading to sleep fragmentation and intermittent …

Physiological regulation of lipoprotein lipase

S Kersten - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2014 - Elsevier
The enzyme lipoprotein lipase (LPL), originally identified as the clearing factor lipase,
hydrolyzes triglycerides present in the triglyceride-rich lipoproteins VLDL and chylomicrons …

Obstructive sleep apnea, hypoxia, and nonalcoholic fatty liver disease

OA Mesarwi, R Loomba, A Malhotra - American journal of …, 2019 - atsjournals.org
Recent studies have demonstrated that obstructive sleep apnea (OSA) is associated with the
development and evolution of nonalcoholic fatty liver disease (NAFLD), independent of …

Endothelial dysfunction in obesity

A Engin - Obesity and lipotoxicity, 2017 - Springer
Chronic inflammatory state in obesity causes dysregulation of the endocrine and paracrine
actions of adipocyte-derived factors, which disrupt vascular homeostasis and contribute to …

Obstructive sleep apnea: an emerging risk factor for atherosclerosis

LF Drager, VY Polotsky, G Lorenzi-Filho - Chest, 2011 - Elsevier
Obstructive sleep apnea (OSA) is independently associated with death from cardiovascular
diseases, including myocardial infarction and stroke. Myocardial infarction and stroke are …

The effect of sleep on gastrointestinal functioning in common digestive diseases

WC Orr, R Fass, SS Sundaram… - The Lancet …, 2020 - thelancet.com
Sleep quality and sleep disorders affect symptom manifestation and the pathogenesis of
digestive diseases. Sleep is largely regulated by the light–dark cycle and associated …

Biological plausibility linking sleep apnoea and metabolic dysfunction

A Gileles-Hillel, L Kheirandish-Gozal… - Nature Reviews …, 2016 - nature.com
Obstructive sleep apnoea (OSA) is a very common disorder that affects 10–25% of the
general population. In the past two decades, OSA has emerged as a cardiometabolic risk …

Sleep apnea and cardiovascular risk in patients with prediabetes and type 2 diabetes

SA Paschou, E Bletsa, K Saltiki, P Kazakou, K Kantreva… - Nutrients, 2022 - mdpi.com
Obstructive sleep apnea (OSA) is a common but largely undiagnosed clinical condition,
which is turning into a serious public health issue. Of note is that its prevalence is gradually …

Obstructive sleep apnea and dyslipidemia: from animal models to clinical evidence

D Barros, F García-Río - Sleep, 2019 - academic.oup.com
Lipid metabolism deregulation constitutes the pathogenic basis for the development of
atherosclerosis and justifies a high incidence of cardiovascular-related morbidity and …