Addiction to protein kinase CK2: a common denominator of diverse cancer cells?
At variance with most oncogenic protein kinases whose malignancy is generally due to
genetic alterations conferring constitutive activity, CK2 is a highly pleiotropic Ser/Thr protein …
genetic alterations conferring constitutive activity, CK2 is a highly pleiotropic Ser/Thr protein …
Protein kinase CK2–a key suppressor of apoptosis
In recent years, evidence has mounted in support of the importance of protein kinase CK2
(previously called casein kinase 2 or II)(EC 2.7. 11.1) in diverse biological processes, and …
(previously called casein kinase 2 or II)(EC 2.7. 11.1) in diverse biological processes, and …
Quercetin: a pleiotropic kinase inhibitor against cancer
Increased consumption of fruits and vegetables can represent an easy strategy to
significantly reduce the incidence of cancer. From this observation, derived mostly from …
significantly reduce the incidence of cancer. From this observation, derived mostly from …
CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells
E Silva-Pavez, P Villar, C Trigo, E Caamaño… - Cell death & …, 2019 - nature.com
Protein kinase CK2 is a highly conserved and constitutively active Ser/Thr-kinase that
phosphorylates a large number of substrates, resulting in increased cell proliferation and …
phosphorylates a large number of substrates, resulting in increased cell proliferation and …
Kinase CK2 inhibition: an update
Protein kinase CK2 (Casein Kinase 2) is an essential, ubiquitous and highly pleiotropic
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …
Curcumin in cancer and inflammation: an in-depth exploration of molecular interactions, therapeutic potentials, and the role in disease management
DO Moon - International Journal of Molecular Sciences, 2024 - mdpi.com
This paper delves into the diverse and significant roles of curcumin, a polyphenolic
compound from the Curcuma longa plant, in the context of cancer and inflammatory …
compound from the Curcuma longa plant, in the context of cancer and inflammatory …
Akt activation enhances ribosomal RNA synthesis through casein kinase II and TIF-IA
LXT Nguyen, BS Mitchell - Proceedings of the National …, 2013 - National Acad Sciences
Transcription initiation factor I (TIF-IA) plays an essential role in regulating ribosomal RNA
(rRNA) synthesis by tethering RNA polymerase I (Pol I) to the rDNA promoter. We have …
(rRNA) synthesis by tethering RNA polymerase I (Pol I) to the rDNA promoter. We have …
Cross-talk between the CK2 and AKT signaling pathways in cancer
CK2 and AKT display a high degree of cross-regulation of their respective functions, both
directly, through physical interaction and phosphorylation, and indirectly, through an intense …
directly, through physical interaction and phosphorylation, and indirectly, through an intense …
Inhibition of CK2α down-regulates Hedgehog/Gli signaling leading to a reduction of a stem-like side population in human lung cancer cells
S Zhang, Y Wang, JH Mao, D Hsieh, IJ Kim, LM Hu… - PloS one, 2012 - journals.plos.org
Protein kinase CK2 is frequently elevated in a variety of human cancers. The Hedgehog
(Hh) signaling pathway has been implicated in stem cell maintenance, and its aberrant …
(Hh) signaling pathway has been implicated in stem cell maintenance, and its aberrant …
Casein kinase II (CK2) as a therapeutic target for hematological malignancies
C Gowda, M Sachdev, S Muthusami… - Current …, 2017 - ingentaconnect.com
Background: Casein kinase II (CK2) is a pro-oncogenic protein, which is emerging as a
promising therapeutic target in cancer. Recent studies have revealed an important role for …
promising therapeutic target in cancer. Recent studies have revealed an important role for …