Airway remodeling heterogeneity in asthma and its relationship to disease outcomes

A Hsieh, N Assadinia, TL Hackett - Frontiers in physiology, 2023 - frontiersin.org
Asthma affects an estimated 262 million people worldwide and caused over 461,000 deaths
in 2019. The disease is characterized by chronic airway inflammation, reversible …

Executive summary: Japanese guidelines for adult asthma (JGL) 2021

A Niimi, K Fukunaga, M Taniguchi… - Allergology …, 2023 - jstage.jst.go.jp
abstract Asthma is characterized by chronic airway inflammation, variable airway narrowing,
and sensory nerve irritation, which manifest as wheezing, dyspnea, chest tightness, and …

Characteristics, phenotypes, mechanisms and management of severe asthma

KF Chung, P Dixey, H Abubakar-Waziri… - Chinese medical …, 2022 - journals.lww.com
Severe asthma is “asthma which requires treatment with high dose inhaled corticosteroids
(ICS) plus a second controller (and/or systemic corticosteroids) to prevent it from becoming …

S2k-Leitlinie zur fachärztlichen Diagnostik und Therapie von Asthma 2023

M Lommatzsch, CP Criée, CCM de Jong… - …, 2023 - thieme-connect.com
Das Management von Asthma hat sich in den letzten Jahrzehnten fundamental gewandelt.
Die vorliegende Leitlinie zur Diagnostik und Therapie von Asthma wurde für pneumologisch …

Holy Grail: the journey towards disease modification in asthma

WW Busse, E Melén… - European Respiratory …, 2022 - Eur Respiratory Soc
At present, there is no cure for asthma, and treatment typically involves therapies that
prevent or reduce asthma symptoms, without modifying the underlying disease. A “disease …

2021 Brazilian Thoracic Association recommendations for the management of severe asthma

RM Carvalho-Pinto, JED Cançado… - Jornal Brasileiro de …, 2021 - SciELO Brasil
Advances in the understanding that severe asthma is a complex and heterogeneous
disease and in the knowledge of the pathophysiology of asthma, with the identification of …

Bronchial thermoplasty in patients with severe asthma at 5 years: the post-FDA approval clinical trial evaluating bronchial thermoplasty in severe persistent asthma …

G Chupp, JN Kline, SB Khatri, C McEvoy, GA Silvestri… - Chest, 2022 - Elsevier
Background Bronchial thermoplasty is a device-based treatment for subjects≥ 18 years of
age with severe asthma poorly controlled with inhaled corticosteroids and long-acting beta …

[HTML][HTML] Research advances in airway remodeling in asthma: a narrative review

Y Huang, C Qiu - Annals of Translational Medicine, 2022 - ncbi.nlm.nih.gov
Research advances in airway remodeling in asthma: a narrative review - PMC Back to Top
Skip to main content NIH NLM Logo Access keys NCBI Homepage MyNCBI Homepage Main …

Effective viral-mediated lung gene therapy: is airway surface preparation necessary?

A McCarron, P Cmielewski, V Drysdale, D Parsons… - Gene Therapy, 2023 - nature.com
Gene-based therapeutics are actively being pursued for the treatment of lung diseases.
While promising advances have been made over the last decades, the absence of clinically …

Advances in asthma: New understandings of asthma's natural history, risk factors, underlying mechanisms, and clinical management

RL Miller, MH Grayson, K Strothman - Journal of Allergy and Clinical …, 2021 - Elsevier
The last 2 years yielded a proliferation of high-quality asthma research. These include new
understandings of the incidence and natural history of asthma, findings on the effects of …