Microglial activation in spaceflight and microgravity: potential risk of cognitive dysfunction and poor neural health
Z Li, J Wu, T Zhao, Y Wei, Y Xu, Z Liu, X Li… - Frontiers in Cellular …, 2024 - frontiersin.org
Due to the increased crewed spaceflights in recent years, it is vital to understand how the
space environment affects human health. A lack of gravitational force is known to risk …
space environment affects human health. A lack of gravitational force is known to risk …
Alleviating symptoms of neurodegenerative disorders by astrocyte-specific overexpression of TMEM164 in mice
L Zhang, Z Jia, Q Wu, T Bai, B Wang, X Hu, T Li… - Nature …, 2023 - nature.com
Neuroinflammatory microglia secrete cytokines to induce neurotoxic reactive astrocytes,
which are one of the major causes of neuronal death. However, the intrinsic key regulators …
which are one of the major causes of neuronal death. However, the intrinsic key regulators …
[HTML][HTML] Orally administered neohesperidin attenuates MPTP-induced neurodegeneration by inhibiting inflammatory responses and regulating intestinal flora in mice
D He, X Gao, J Wen, Y Zhang, S Yang, X Sun, M Cui… - Food & Function, 2024 - pubs.rsc.org
Parkinson's disease (PD), a neurodegenerative disease, is the leading cause of movement
disorders. Neuroinflammation plays a critical role in PD pathogenesis. Neohesperidin (Neo) …
disorders. Neuroinflammation plays a critical role in PD pathogenesis. Neohesperidin (Neo) …
[HTML][HTML] Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-κB Pro-inflammatory Signaling in Ischemic Reperfusion Injury
X Tian, W Yang, W Jiang, Z Zhang, J Liu… - Molecular & Cellular …, 2024 - ASBMB
Cerebral stroke is one of the leading causes of mortality and disability worldwide. Restoring
the cerebral circulation following a period of occlusion and subsequent tissue oxygenation …
the cerebral circulation following a period of occlusion and subsequent tissue oxygenation …
Cannabidiol ameliorates PTSD-like symptoms by inhibiting neuroinflammation through its action on CB2 receptors in the brain of male mice
G Xie, X Gao, Q Guo, H Liang, L Yao, W Li, B Ma… - Brain, Behavior, and …, 2024 - Elsevier
Post-traumatic stress disorder (PTSD) is a debilitating mental health disease related to
traumatic experience, and its treatment outcomes are unsatisfactory. Accumulating research …
traumatic experience, and its treatment outcomes are unsatisfactory. Accumulating research …
[HTML][HTML] Diosgenin alters LPS-induced macrophage polarization by activating PPARγ/NF-κB signaling pathway
X Xiang, X Xin, Y Hou, Y Deng, X Liu, W Yu - International …, 2024 - Elsevier
Diosgenin (DG) is a steroidal saponin derived from plants, and it exhibits anti-inflammatory
properties. In this study, we employed an in vitro model of Pg-LPS-stimulated mouse …
properties. In this study, we employed an in vitro model of Pg-LPS-stimulated mouse …
Frataxin deficiency shifts metabolism to promote reactive microglia via glucose catabolism
F Sciarretta, F Zaccaria, A Ninni, V Ceci… - Life Science …, 2024 - life-science-alliance.org
Immunometabolism investigates the intricate relationship between the immune system and
cellular metabolism. This study delves into the consequences of mitochondrial frataxin (FXN) …
cellular metabolism. This study delves into the consequences of mitochondrial frataxin (FXN) …