Pharmacokinetic characteristics of long-acting injectable antipsychotics for schizophrenia: an overview

CU Correll, E Kim, JK Sliwa, W Hamm, S Gopal… - CNS drugs, 2021 - Springer
The availability of long-acting injectable (LAI) antipsychotics for the treatment of
schizophrenia provides clinicians with options that deliver continuous drug exposure and …

Prodrug approaches for the development of a long-acting drug delivery systems

ST Chien, IT Suydam, KA Woodrow - Advanced Drug Delivery Reviews, 2023 - Elsevier
Long-acting formulations are designed to reduce dosing frequency and simplify dosing
schedules by providing an extended duration of action. One approach to obtain long-acting …

New antipsychotic medications in the last decade

M Pahwa, A Sleem, OH Elsayed, ME Good… - Current Psychiatry …, 2021 - Springer
Abstract Purpose of Review Over the last ten years, the treatment of psychosis has seen a
near explosion of creative development in both novel agents and new delivery modalities …

Pharmacokinetics of long-acting aqueous nano-/microsuspensions after intramuscular administration in different animal species and humans—a review

VTT Nguyen, N Darville, A Vermeulen - The AAPS Journal, 2022 - Springer
Formulating aqueous suspensions is an attractive strategy to incorporate poorly water-
soluble drugs, where the drug release can be tailored to maintain desired release profiles of …

Long-acting injectable second-generation antipsychotics: an update and comparison between agents

MW Jann, SR Penzak - CNS drugs, 2018 - Springer
Schizophrenia is a chronic medical condition with periods of remission and relapses over a
patient's lifetime. Antipsychotic medications represent the mainstay of treatment for this …

Therapeutic drug monitoring of long-acting injectable antipsychotic drugs

G Schoretsanitis, P Baumann, A Conca… - Therapeutic drug …, 2021 - journals.lww.com
Background: The use of therapeutic drug monitoring (TDM) to guide treatment with long-
acting injectable (LAI) antipsychotics, which are increasingly prescribed, remains a matter of …

Current and emerging long-acting antipsychotics for the treatment of schizophrenia

R de Filippis, P De Fazio, R Gaetano… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: In this review, the authors discuss the role of long-acting injectable
antipsychotics (LAIs) for schizophrenia, focusing on the effectiveness and new perspectives …

Review of pharmacokinetics and pharmacogenetics in atypical long-acting injectable antipsychotics

FJ Toja-Camba, N Gesto-Antelo, O Maroñas… - Pharmaceutics, 2021 - mdpi.com
Over the last two decades, pharmacogenetics and pharmacokinetics have been increasingly
used in clinical practice in Psychiatry due to the high variability regarding response and side …

Long-acting injectable antipsychotics—a review on formulation and in vitro dissolution

M Markowicz-Piasecka, M Kubisiak, K Asendrych-Wicik… - Pharmaceutics, 2023 - mdpi.com
Long-acting injectable (LAI) neuroleptics constitute an effective therapeutical alternative for
individuals suffering from persistent mental illness. These injectable pharmaceuticals help …

Practical guidance for the use of long-acting injectable antipsychotics in the treatment of schizophrenia

I Riboldi, D Cavaleri, CA Capogrosso… - Psychology Research …, 2022 - Taylor & Francis
Schizophrenia is a severe mental illness causing a high degree of disability. First-and
second-generation antipsychotics (FGAs and SGAs) represent key resources for its acute …