UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies

ME Terlizzi, G Gribaudo, ME Maffei - Frontiers in microbiology, 2017 - frontiersin.org
Urinary tract infections (UTIs) are one of the most common pathological conditions in both
community and hospital settings. It has been estimated that about 150 million people …

Resolving host–pathogen interactions by dual RNA-seq

AJ Westermann, L Barquist, J Vogel - PLoS pathogens, 2017 - journals.plos.org
The transcriptome is a powerful proxy for the physiological state of a cell, healthy or
diseased. As a result, transcriptome analysis has become a key tool in understanding the …

Cross-species RNA-seq for deciphering host–microbe interactions

AJ Westermann, J Vogel - Nature Reviews Genetics, 2021 - nature.com
The human body is constantly exposed to microorganisms, which entails manifold
interactions between human cells and diverse commensal or pathogenic bacteria. The …

Bacterial diversity of diabetic foot ulcers: current status and future prospectives

F Sadeghpour Heravi, M Zakrzewski, K Vickery… - Journal of clinical …, 2019 - mdpi.com
Diabetic foot ulcers (DFUs) and diabetic foot infections (DFIs) are associated with reduced
patient quality of life, lower-extremity amputation, hospitalization, and high morbidity and …

Spatially distinct physiology of Bacteroides fragilis within the proximal colon of gnotobiotic mice

GP Donaldson, WC Chou, AL Manson, P Rogov… - Nature …, 2020 - nature.com
A complex microbiota inhabits various microenvironments of the gut, with some symbiotic
bacteria having evolved traits to invade the epithelial mucus layer and reside deep within …

New RNA-seq approaches for the study of bacterial pathogens

AE Saliba, SC Santos, J Vogel - Current opinion in microbiology, 2017 - Elsevier
Highlights•A surge of new RNA-seq based methods to study bacterial pathogenesis.•RIP-
seq, CLIP-seq, CLASH, RIL-seq, GRIL-seq, MAPS and Term-seq discover new RNA-based …

Invasion of host cells and tissues by uropathogenic bacteria

AJ Lewis, AC Richards… - Urinary Tract Infections …, 2017 - Wiley Online Library
The ability of bacterial pathogens to invade host cells can have profound effects on the
establishment, persistence, and propagation of infections. By entering host cells and …

Chicken‐source Escherichia coli within phylogroup F shares virulence genotypes and is closely related to extraintestinal pathogenic E. coli causing human infections

X Zhuge, Z Zhou, M Jiang, Z Wang… - Transboundary and …, 2021 - Wiley Online Library
ExPEC is an important pathogen that causes diverse infection in the human extraintestinal
sites. Although avian‐source phylogroup F Escherichia coli isolates hold a high level of …

Path‐seq identifies an essential mycolate remodeling program for mycobacterial host adaptation

EJR Peterson, R Bailo, AC Rothchild… - Molecular systems …, 2019 - embopress.org
The success of Mycobacterium tuberculosis (MTB) stems from its ability to remain hidden
from the immune system within macrophages. Here, we report a new technology (Path‐seq) …

Exosomes derived from bladder epithelial cells infected with uropathogenic Escherichia coli increase the severity of urinary tract infections (UTIs) by impairing …

Z Wang, Z Jiang, Y Zhang, C Wang, Z Liu, Z Jia… - PLoS …, 2024 - journals.plos.org
Uropathogenic Escherichia coli (UPEC) is the primary causative agent of urinary tract
infections (UTIs) in humans. Moreover, as one of the most common bacterial pathogens …