Small RNA molecules have been known and utilized to suppress gene expression for more
than a decade. The discovery that these small RNA molecules are endogenously expressed …

Cell survival depends on the precise and correct production of polypeptides. Eukaryotic cells
have evolved conserved proofreading mechanisms to get rid of incomplete and potentially …

In many cervical cancers, human papillomavirus type 16 (HPV-16) DNA genomes are found
to be integrated into the host chromosome. In this study, we demonstrate that integration of …

Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases,
such as G3BP, a phosphorylation-dependent endoribonuclease that associates with …

The N channel is critical for regulating release of neurotransmitter at many synapses, and
even subtle differences in its activity would be expected to influence the efficacy of synaptic …

Interleukin-6 mRNA is unstable and degraded with a half-life of 30 min. Instability
determinants can entirely be attributed to the 3′ untranslated region. By grafting segments …

The pathogenesis of septicemia can be triggered by LPS, a potent stimulus for PG synthesis.
The enzyme cyclooxygenase (COX) is a rate-limiting step in PG production. COX exists as …

The glial cell line-derived neurotrophic factor (GDNF) is required for the survival and
differentiation of diverse neuronal populations during nervous system development. Despite …

The stability of several oncogene, cytokine, and growth factor transcripts is tightly regulated
by signaling pathways through an ARE (AU-rich element) present in their 3′-UTRs. We …

The positive-sense transcripts of Sindbis virus (SINV) resemble cellular mRNAs in that they
possess a 5′ cap and a 3′ poly (A) tail. It is likely, therefore, that SINV RNAs must …