Highlights•Cells other than leukocytes can be essential for protective immunity in
humans.•Human inborn errors of immunity to infection can affect non-professional cells …

Griscelli syndrome type 2 (GS-2) is an inborn error of immunity characterized by partial
albinism and episodes of hemophagocytic lymphohistiocytosis (HLH). It is caused by …

Highlights•The incompletely penetrant association of IL-17/IL-22 AAbs with CMC and
evidence from clinical IL-17 mAbs and genetic IL-10RB deficiency imply these AAbs may not …

STAT2 is a transcription factor that plays an essential role in antiviral immunity by mediating
the activity of type I and III interferons (IFN-I and IFN-III). It also has a recently established …

We present a case of complete deficiency of the interferon alpha/beta receptor alpha chain
(IFNAR1) in a child with fatal systemic hyperinflammation, apparently provoked by live …

Enterovirus (EV) infection rarely results in life-threatening infection of the central nervous
system. We report two unrelated children with EV30 and EV71 rhombencephalitis. One …

The field of Immunology is one that has undergone great expansion in recent years. With the
advent of new diagnostic modalities including a variety of genetic tests (discussed …

Precision medicine approaches based on pharmacogenomics are now being successfully
implemented to enable physicians to predict more efficient treatments and prevention …

Since the beginning of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-
2)/coronavirus disease 2019 (COVID-19) pandemic, global sequencing efforts have led in …

Background Recognition of viral nucleic acids is one of the primary triggers for a type I
interferon–mediated antiviral immune response. Inborn errors of type I interferon immunity …