Crohn's disease
G Roda, S Chien Ng, PG Kotze, M Argollo… - Nature Reviews …, 2020 - nature.com
Crohn's disease is an inflammatory bowel disease that is characterized by chronic
inflammation of any part of the gastrointestinal tract, has a progressive and destructive …
inflammation of any part of the gastrointestinal tract, has a progressive and destructive …
Targeting immune cell circuits and trafficking in inflammatory bowel disease
MF Neurath - Nature immunology, 2019 - nature.com
Inflammatory bowel diseases (IBDs) such as Crohn's disease and ulcerative colitis are
characterized by uncontrolled activation of intestinal immune cells in a genetically …
characterized by uncontrolled activation of intestinal immune cells in a genetically …
Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
Z Liu, R Liu, H Gao, S Jung, X Gao, R Sun, X Liu… - Nature …, 2023 - nature.com
Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract with
the following two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most …
the following two subtypes: Crohn's disease (CD) and ulcerative colitis (UC). To date, most …
[PDF][PDF] Genomic dissection of bipolar disorder and schizophrenia, including 28 subphenotypes
DM Ruderfer, S Ripke, A McQuillin, J Boocock… - Cell, 2018 - cell.com
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology.
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …
Understanding the genetic factors contributing to the shared and disorder-specific symptoms …
[PDF][PDF] Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 2: current management
M Harbord, R Eliakim, D Bettenworth… - Journal of Crohn's …, 2017 - academic.oup.com
11.1. General The treatment strategy for ulcerative colitis [UC] is mainly based on the
severity, distribution [proctitis, left-sided, extensive] 1 and pattern of disease. The latter …
severity, distribution [proctitis, left-sided, extensive] 1 and pattern of disease. The latter …
IL-12, IL-23 and IL-17 in IBD: immunobiology and therapeutic targeting
AR Moschen, H Tilg, T Raine - Nature Reviews Gastroenterology & …, 2019 - nature.com
Abstract IL-12 and IL-23 are closely related cytokines with important roles in the regulation of
tissue inflammation. Converging evidence from studies in mice, human observational …
tissue inflammation. Converging evidence from studies in mice, human observational …
[HTML][HTML] Ulcerative colitis: Recent advances in the understanding of disease pathogenesis
RJ Porter, R Kalla, GT Ho - F1000Research, 2020 - ncbi.nlm.nih.gov
Inflammatory bowel diseases are common, complex, immune-mediated conditions with a
sharply rising global prevalence. While major advances since 2000 have provided strong …
sharply rising global prevalence. While major advances since 2000 have provided strong …
Crohn disease: epidemiology, diagnosis, and management
JD Feuerstein, AS Cheifetz - Mayo Clinic Proceedings, 2017 - Elsevier
Crohn disease is a chronic idiopathic inflammatory bowel disease condition characterized
by skip lesions and transmural inflammation that can affect the entire gastrointestinal tract …
by skip lesions and transmural inflammation that can affect the entire gastrointestinal tract …
The landscape of immune dysregulation in Crohn's disease revealed through single-cell transcriptomic profiling in the ileum and colon
L Kong, V Pokatayev, A Lefkovith, GT Carter… - Immunity, 2023 - cell.com
Crohn's disease (CD) is a chronic gastrointestinal disease that is increasing in prevalence
worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and …
worldwide. CD is multifactorial, involving the complex interplay of genetic, immune, and …
Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Ulcerative colitis and Crohn's disease are the two main forms of inflammatory bowel disease
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …
(IBD). Here we report the first trans-ancestry association study of IBD, with genome-wide or …