Neurodegeneration, the slow and progressive dysfunction and loss of neurons and axons in
the central nervous system, is the primary pathological feature of acute and chronic …

Neurodegeneration, the progressive dysfunction and loss of neurons in the central nervous
system (CNS), is the major cause of cognitive and motor dysfunction. While neuronal …

Multiple sclerosis (MS) is a chronic, progressive disorder of the central nervous system
(CNS) that affects more than two million people worldwide. Several animal models resemble …

In view of disease heterogeneity of multiple sclerosis and limited access to ex vivo
specimens, different approaches must be undertaken to better understand disease …

Cognitive impairment (CI) is a disabling concomitant of multiple sclerosis (MS) with a
complex and controversial pathogenesis. The cytokine interleukin-17A (IL-17A) is involved …

Multiple sclerosis is the most common inflammatory demyelinating disease of the central
nervous system, caused by an autoimmune response against myelin that eventually leads to …

Demyelinating diseases such as multiple sclerosis are chronic inflammatory autoimmune
diseases with a heterogeneous clinical presentation and course. Both the adaptive and the …

The central nervous system (CNS) and the immune system are known to be engaged in an
intense bidirectional crosstalk. In particular, the immune system has the potential to …

Multiple sclerosis (MS) is an autoimmune disease characterized by peripheral activation of
CD4+ T cells that migrate into the central nervous system (CNS) and mount an autoimmune …

It is over 125 years since Ilya Metchnikoff described the significance of phagocytosis. In this
review, we examine the early origins and development of macrophage research continuing …