Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis

DJ Hicklin, LM Ellis - Journal of clinical oncology, 2005 - ascopubs.org
New blood vessel formation (angiogenesis) is a fundamental event in the process of tumor
growth and metastatic dissemination. Hence, the molecular basis of tumor angiogenesis has …

Pathophysiology of diabetic retinopathy

MW Stewart - Diabetic retinopathy: evidence-based management, 2010 - Springer
The retina was first described by Herophilus of Chalcedon around 300 bc. It was named by
Rufos of Ephesus (c. 110 ad) and appeared to early anatomists as a surrounding net which …

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

Y Wang, M Nakayama, ME Pitulescu, TS Schmidt… - Nature, 2010 - nature.com
In development, tissue regeneration or certain diseases, angiogenic growth leads to the
expansion of blood vessels and the lymphatic vasculature. This involves endothelial cell …

[PDF][PDF] Role of angiogenesis and angiogenic factors in acute and chronic wound healing

TM Honnegowda, P Kumar, EGP Udupa… - Plastic and Aesthetic …, 2015 - researchgate.net
Angiogenesis plays a crucial role in wound healing by forming new blood vessels from
preexisting vessels by invading the wound clot and organizing into a microvascular network …

Vascular endothelial growth factor receptor-2: structure, function, intracellular signalling and therapeutic inhibition

K Holmes, OL Roberts, AM Thomas, MJ Cross - Cellular signalling, 2007 - Elsevier
Vascular endothelial growth factors (VEGFs) regulate vascular development, angiogenesis
and lymphangiogenesis by binding to a number of receptors. VEGFR-1 is required for the …

Vascular endothelial growth factors and angiogenesis in eye disease

AN Witmer, G Vrensen, CJF Van Noorden… - Progress in retinal and …, 2003 - Elsevier
The vascular endothelial growth factor (VEGF) family of growth factors controls pathological
angiogenesis and increased vascular permeability in important eye diseases such as …

Anti-angiogenic tyrosine kinase inhibitors: what is their mechanism of action?

KJ Gotink, HMW Verheul - Angiogenesis, 2010 - Springer
Tyrosine kinases are important cellular signaling proteins that have a variety of biological
activities including cell proliferation and migration. Multiple kinases are involved in …

Minoxidil: mechanisms of action on hair growth

AG Messenger, J Rundegren - British journal of dermatology, 2004 - academic.oup.com
We have known for over 30 years that minoxidil stimulates hair growth, yet our
understanding of its mechanism of action on the hair follicle is very limited. In animal studies …

Angiogenic and cell survival functions of vascular endothelial growth factor (VEGF)

AM Byrne, DJ Bouchier‐Hayes… - Journal of cellular and …, 2005 - Wiley Online Library
Vascular endothelial growth factor (VEGF) was originally identified as an endothelial cell
specific growth factor stimulating angiogenesis and vascular permeability. Some family …

The biology of vascular endothelial growth factors

T Tammela, B Enholm, K Alitalo… - Cardiovascular …, 2005 - academic.oup.com
The discovery of the vascular endothelial growth factor (VEGF) family members VEGF, VEGF-
B, placental growth factor (PlGF), VEGF-C and VEGF-D and their receptors VEGFR-1,-2 and …