Although creatine has been mostly studied as an ergogenic aid for exercise, training, and
sport, several health and potential therapeutic benefits have been reported. This is because …

While the vast majority of research involving creatine supplementation has focused on
skeletal muscle, there is a small body of accumulating research that has focused on creatine …

Wnt signaling affects fundamental development pathways and, if aberrantly activated,
promotes the development of cancers. Wnt signaling is modulated by different factors, but …

Creatine is pivotal in energy metabolism of muscle and brain cells, both in physiological and
in pathological conditions. Additionally, creatine facilitates the differentiation of muscle and …

Newborn neurons in the adult hippocampus are regulated by many intrinsic and extrinsic
cues. It is well accepted that elevated glucocorticoid levels lead to downregulation of adult …

In addition to its role as a neuronal energy substrate and signaling molecule involved in
synaptic plasticity and memory consolidation, recent evidence shows that lactate produces …

Suicide and major depressive disorder (MDD) are complex conditions that almost certainly
arise from the influences of many interrelated factors. There are significant regional …

Depression is one of the most frequent neuropsychiatric diseases in the western world and
its physiological causes are not yet fully understood. Since the available antidepressants …

Physical exercise has been shown to exert antidepressant effects, but the mechanisms
underlying this effect are not completely elucidated. Therefore, we aimed at investigating the …

Depression is a neuropsychiatry medical condition with high prevalence, in which the
hypothalamic-pituitary-adrenal axis dysfunction has been postulated as the main cause. The …