mTORC1-dependent signaling pathway underlies the rapid effect of creatine and ketamine in the novelty-suppressed feeding test
The development of fast-acting antidepressants is crucial considering that conventional
antidepressants require a long period to elicit therapeutic effects. Creatine, an ergogenic …
antidepressants require a long period to elicit therapeutic effects. Creatine, an ergogenic …
Regulation of tau protein on the antidepressant effects of ketamine in the chronic unpredictable mild stress model
G Wen, H Yao, Y Li, R Ding, X Ren, Y Tan… - Frontiers in …, 2019 - frontiersin.org
Tau protein is known to play an important role in maintaining microtubule assembly and
stabilization, and maintaining the normal morphology of neurons, but several studies have …
stabilization, and maintaining the normal morphology of neurons, but several studies have …
[HTML][HTML] Antidepressant and pro-neurogenic effects of agmatine in a mouse model of stress induced by chronic exposure to corticosterone
G Olescowicz, VB Neis, DB Fraga, PB Rosa… - Progress in Neuro …, 2018 - Elsevier
Agmatine is an endogenous neuromodulator that has been shown to have beneficial effects
in the central nervous system, including antidepressant-like effects in animals. In this study …
in the central nervous system, including antidepressant-like effects in animals. In this study …
The possible beneficial effects of creatine for the management of depression
Depression, a highly prevalent neuropsychiatric disorder worldwide, causes a heavy burden
for the society and is associated with suicide risk. The treatment of this disorder remains a …
for the society and is associated with suicide risk. The treatment of this disorder remains a …
Ketamine, but not fluoxetine, rapidly rescues corticosterone-induced impairments on glucocorticoid receptor and dendritic branching in the hippocampus of mice
DB Fraga, A Camargo, G Olescowicz, DA Padilha… - Metabolic brain …, 2021 - Springer
Although numerous studies have investigated the mechanisms underlying the fast and
sustained antidepressant-like effects of ketamine, the contribution of the glucocorticoid …
sustained antidepressant-like effects of ketamine, the contribution of the glucocorticoid …
[HTML][HTML] Intradialytic creatine supplementation: A scientific rationale for improving the health and quality of life of dialysis patients
T Wallimann, U Riek, M Möddel - Medical hypotheses, 2017 - Elsevier
The CK/PCr-system, with creatine (Cr) as an energy precursor, plays a crucial role in cellular
physiology. In the kidney, as in other organs and cells with high and fluctuating energy …
physiology. In the kidney, as in other organs and cells with high and fluctuating energy …
Physical exercise stimulates hippocampal mTORC1 and FNDC5/irisin signaling pathway in mice: Possible implication for its antidepressant effect
Several lines of evidence have consistently indicated that physical exercise has
antidepressant effects by improving hippocampal function, although the signaling pathways …
antidepressant effects by improving hippocampal function, although the signaling pathways …
Morus nigra leaves extract revokes the depressive-like behavior, oxidative stress, and hippocampal damage induced by corticosterone: a pivotal role of the phenolic …
The pathophysiology of depression includes glucocorticoids excess, glutamatergic
excitotoxicity, and oxidative stress impairment. Previous study demonstrated Morus nigra L …
excitotoxicity, and oxidative stress impairment. Previous study demonstrated Morus nigra L …
Involvement of heme oxygenase-1 in neuropsychiatric and neurodegenerative diseases
Heme oxygenase (HO) family catalyzes the conversion of heme into free iron, carbon
monoxide and biliverdin. It possesses two well-characterized isoforms: HO-1 and HO-2 …
monoxide and biliverdin. It possesses two well-characterized isoforms: HO-1 and HO-2 …
[HTML][HTML] Prophylactic effect of physical exercise on Aβ1–40-induced depressive-like behavior: Role of BDNF, mTOR signaling, cell proliferation and survival in the …
Alzheimer's disease (AD) is characterized by progressive cognitive impairments as well as
non-cognitive symptoms such as depressed mood. Physical exercise has been proposed as …
non-cognitive symptoms such as depressed mood. Physical exercise has been proposed as …