Single administration of agmatine reverses the depressive-like behavior induced by corticosterone in mice: comparison with ketamine and fluoxetine
Agmatine is a neuromodulator that has been proposed as a therapeutic strategy for the
treatment of major depressive disorder (MDD). A previous study reported that agmatine …
treatment of major depressive disorder (MDD). A previous study reported that agmatine …
The Association Between Antidepressant Effect of SSRIs and Astrocytes: Conceptual Overview and Meta‐analysis of the Literature
B Chen, M Zhang, M Ji, W Gong, B Chen, R Zorec… - Neurochemical …, 2021 - Springer
Major depressive disorders (MDD) a worldwide psychiatric disease, is yet to be adequately
controlled by therapies; while the mechanisms of action of antidepressants are yet to be fully …
controlled by therapies; while the mechanisms of action of antidepressants are yet to be fully …
Subchronic administration of creatine produces antidepressant-like effect by modulating hippocampal signaling pathway mediated by FNDC5/BDNF/Akt in mice
Creatine has been shown to play a significant role in the pathophysiology and treatment of
major depressive disorder (MDD) in preclinical and clinical studies. However, the biological …
major depressive disorder (MDD) in preclinical and clinical studies. However, the biological …
Exploring the Pathophysiological Influence of Heme Oxygenase-1 on Neuroinflammation and Depression: A Study of Phytotherapeutic-Based Modulation
Background The heme oxygenase (HO) system plays a significant role in neuroprotection
and reduction of neuroinflammation and neurodegeneration. The system, via isoforms HO-1 …
and reduction of neuroinflammation and neurodegeneration. The system, via isoforms HO-1 …
The effect of scutellaria baicalensis and its active ingredients on major depressive disorder: a systematic review and meta-analysis of literature in pre-clinical research
Y Ma, X Zhou, F Zhang, C Huang, H Yang… - Frontiers in …, 2024 - frontiersin.org
Background: Scutellaria baicalensis, the dry root of scutellaria baicalensis georgi, is a
traditional Chinese medicine with long. In clinic, scutellaria baicalensis is commonly used in …
traditional Chinese medicine with long. In clinic, scutellaria baicalensis is commonly used in …
Antidepressant effects of creatine on amyloid β1–40-treated mice: the role of GSK-3β/Nrf2 pathway
Alzheimer's disease (AD) is characterized by progressive synaptic dysfunction and neuronal
lost in specific brain areas including hippocampus, resulting in memory/learning deficits and …
lost in specific brain areas including hippocampus, resulting in memory/learning deficits and …
20(S)-Protopanaxadiol Exerts Antidepressive Effects in Chronic Corticosterone-Induced Rodent Animal Models as an Activator of Brain-Type Creatine Kinase
Z Zhu, Y Cheng, X Han, T Wang, H Zhang… - Journal of Agricultural …, 2024 - ACS Publications
20 (S)-Protopanaxadiol (PPD) is one of the bioactive ingredients in ginseng and possesses
neuroprotective properties. Brain-type creatine kinase (CK-BB) is an enzyme involved in …
neuroprotective properties. Brain-type creatine kinase (CK-BB) is an enzyme involved in …
Enriched environment ameliorates dexamethasone effects on emotional reactivity and metabolic parameters in mice
E Delanogare, RM de Souza, GK Rosa, FG Guanabara… - Stress, 2020 - Taylor & Francis
Convincing evidence shows that stress is associated with the development and course of
psychiatric and metabolic disorders. The hypothalamic-pituitary-adrenal (HPA) axis …
psychiatric and metabolic disorders. The hypothalamic-pituitary-adrenal (HPA) axis …
ACE gene polymorphisms (rs4340) II and DI are more responsive to the ergogenic effect of caffeine than DD on aerobic power, heart rate, and perceived exertion in a …
The purpose of this study was to verify the association between angiotensin-converting
enzyme (ACE) genotypes DD, DI, and II and caffeine (CAF) ingestion on endurance …
enzyme (ACE) genotypes DD, DI, and II and caffeine (CAF) ingestion on endurance …
Protective effects of agmatine against corticosterone-induced impairment on hippocampal mTOR signaling and cell death
G Olescowicz, TB Sampaio… - Neurotoxicity …, 2020 - Springer
Chronic treatment with agmatine, similarly to fluoxetine, may cause antidepressant-like
effects mediated, at least in part, by the modulation of hippocampal plasticity. However, the …
effects mediated, at least in part, by the modulation of hippocampal plasticity. However, the …