Molecular pathogenesis and systemic therapies for hepatocellular carcinoma

JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …

Changing epidemiology of hepatocellular carcinoma in Asia

C Zhang, Y Cheng, S Zhang, J Fan, Q Gao - Liver International, 2022 - Wiley Online Library
Liver cancer is the fifth most common cancer and the second leading cause of malignant
death in Asia, and Asia reports 72.5% of the world's cases in 2020. As the most common …

Tremelimumab plus durvalumab in unresectable hepatocellular carcinoma

GK Abou-Alfa, G Lau, M Kudo, SL Chan… - NEJM …, 2022 - evidence.nejm.org
Background A single, high priming dose of tremelimumab (anti-cytotoxic T lymphocyte–
associated antigen 4) plus durvalumab (anti–programmed cell death ligand-1), an infusion …

Lenvatinib combined with transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma: a phase III, randomized clinical trial …

Z Peng, W Fan, B Zhu, G Wang, J Sun… - Journal of Clinical …, 2023 - ingentaconnect.com
PURPOSE Lenvatinib (LEN) is a first-line therapy for patients with advanced hepatocellular
carcinoma (HCC); however, it has shown modest survival benefits. Therefore, we aimed to …

Gallbladder cancer

JC Roa, P García, VK Kapoor, SK Maithel… - Nature reviews Disease …, 2022 - nature.com
Gallbladder cancer (GBC) is the most common cancer of the biliary tract, characterized by a
very poor prognosis when diagnosed at advanced stages owing to its aggressive behaviour …

Immunology and immunotherapy of cholangiocarcinoma

TF Greten, R Schwabe, N Bardeesy, L Ma… - Nature Reviews …, 2023 - nature.com
Cholangiocarcinoma is the second most common primary liver cancer. Its incidence is low in
the Western world but is rising globally. Surgery, chemotherapy and radiation therapy have …

The clinical management of hepatocellular carcinoma worldwide: A concise review and comparison of current guidelines: 2022 update

N Wen, Y Cai, F Li, H Ye, W Tang, P Song… - Bioscience …, 2022 - jstage.jst.go.jp
Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the second
leading cause of cancer-related mortality worldwide. This review is an updated version that …

[HTML][HTML] Lenvatinib, toripalimab plus hepatic arterial infusion chemotherapy in patients with high-risk advanced hepatocellular carcinoma: a biomolecular exploratory …

ZC Lai, MK He, XY Bu, YJ Xu, YX Huang… - European Journal of …, 2022 - Elsevier
Introduction The combination of lenvatinib, toripalimab and hepatic arterial infusion
chemotherapy (HAIC) with oxaliplatin, leucovorin, and 5-fluorouracil (FOLFOX) suggested …

[HTML][HTML] Validation of a novel multitarget blood test shows high sensitivity to detect early stage hepatocellular carcinoma

NP Chalasani, K Porter, A Bhattacharya… - Clinical …, 2022 - Elsevier
Background & Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer-related
death worldwide. Although biannual ultrasound surveillance with or without α-fetoprotein …

Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …