Molecular pathogenesis and systemic therapies for hepatocellular carcinoma
JM Llovet, R Pinyol, RK Kelley, A El-Khoueiry… - Nature cancer, 2022 - nature.com
Hepatocellular carcinoma (HCC) remains one of the most prevalent and deadliest cancers.
The poor outcome associated with HCC is dramatically changing due to the advent of …
The poor outcome associated with HCC is dramatically changing due to the advent of …
Changing epidemiology of hepatocellular carcinoma in Asia
C Zhang, Y Cheng, S Zhang, J Fan, Q Gao - Liver International, 2022 - Wiley Online Library
Liver cancer is the fifth most common cancer and the second leading cause of malignant
death in Asia, and Asia reports 72.5% of the world's cases in 2020. As the most common …
death in Asia, and Asia reports 72.5% of the world's cases in 2020. As the most common …
Tremelimumab plus durvalumab in unresectable hepatocellular carcinoma
GK Abou-Alfa, G Lau, M Kudo, SL Chan… - NEJM …, 2022 - evidence.nejm.org
Background A single, high priming dose of tremelimumab (anti-cytotoxic T lymphocyte–
associated antigen 4) plus durvalumab (anti–programmed cell death ligand-1), an infusion …
associated antigen 4) plus durvalumab (anti–programmed cell death ligand-1), an infusion …
Lenvatinib combined with transarterial chemoembolization as first-line treatment for advanced hepatocellular carcinoma: a phase III, randomized clinical trial …
Z Peng, W Fan, B Zhu, G Wang, J Sun… - Journal of Clinical …, 2023 - ingentaconnect.com
PURPOSE Lenvatinib (LEN) is a first-line therapy for patients with advanced hepatocellular
carcinoma (HCC); however, it has shown modest survival benefits. Therefore, we aimed to …
carcinoma (HCC); however, it has shown modest survival benefits. Therefore, we aimed to …
Gallbladder cancer
Gallbladder cancer (GBC) is the most common cancer of the biliary tract, characterized by a
very poor prognosis when diagnosed at advanced stages owing to its aggressive behaviour …
very poor prognosis when diagnosed at advanced stages owing to its aggressive behaviour …
Immunology and immunotherapy of cholangiocarcinoma
Cholangiocarcinoma is the second most common primary liver cancer. Its incidence is low in
the Western world but is rising globally. Surgery, chemotherapy and radiation therapy have …
the Western world but is rising globally. Surgery, chemotherapy and radiation therapy have …
The clinical management of hepatocellular carcinoma worldwide: A concise review and comparison of current guidelines: 2022 update
N Wen, Y Cai, F Li, H Ye, W Tang, P Song… - Bioscience …, 2022 - jstage.jst.go.jp
Hepatocellular carcinoma (HCC) is the fifth most common malignancy and the second
leading cause of cancer-related mortality worldwide. This review is an updated version that …
leading cause of cancer-related mortality worldwide. This review is an updated version that …
[HTML][HTML] Lenvatinib, toripalimab plus hepatic arterial infusion chemotherapy in patients with high-risk advanced hepatocellular carcinoma: a biomolecular exploratory …
ZC Lai, MK He, XY Bu, YJ Xu, YX Huang… - European Journal of …, 2022 - Elsevier
Introduction The combination of lenvatinib, toripalimab and hepatic arterial infusion
chemotherapy (HAIC) with oxaliplatin, leucovorin, and 5-fluorouracil (FOLFOX) suggested …
chemotherapy (HAIC) with oxaliplatin, leucovorin, and 5-fluorouracil (FOLFOX) suggested …
[HTML][HTML] Validation of a novel multitarget blood test shows high sensitivity to detect early stage hepatocellular carcinoma
Background & Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer-related
death worldwide. Although biannual ultrasound surveillance with or without α-fetoprotein …
death worldwide. Although biannual ultrasound surveillance with or without α-fetoprotein …
Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …