Abstract Background Transplantation of allogenic Langerhans islets (ISL) has been
employed as an alternative to pancreas transplantation to provide endogenous supply of …

Aims The exposure of isolated pancreatic islets to pro-angiogenic factors prior to their
transplantation represents a promising strategy to accelerate the revascularization of the …

We previously reported that treatment with a JNK inhibitory peptide (11R-JNKI) prevents islet
apoptosis and enhances the islet function in vivo. In the present study, we explored more …

Islet transplantation in man is limited by multiple factors including islet availability, islet cell
damage caused by collagenase during isolation, maintenance of islet function between …

Hypoxia-induced islet cell death, caused by an insufficient revascularization of the grafts, is
a major obstacle for successful pancreatic islet transplantation. Recently, it has been …

The in vitro culture period prior to cell transplantation (ie pancreatic islet transplantation)
enables cell modification and is thus advantageous. However, the islet preconditioning …

Background and aims: Chronic pancreatitis may cause intractable abdominal pain, with total
pancreatectomy sometimes being the last resort. To mitigate the subsequent diabetes, total …

Islet culture prior to transplantation is a standard practice in many transplantation centers.
Nevertheless, the abundant islet mass loss and function impairment during this serum …

Background. Pancreas and islet transplantation outcomes are negatively impacted by injury
to the endocrine cells from acute stress during donor death, organ procurement, processing …

Diabetes care has undergone one of the most notable revolutions in the history of medicine.
Whole pancreas and islet cell transplantation are robust and safe options for people with …