Islet transplantation is a promising treatment strategy for type 1 diabetes mellitus (T1DM)
patients. However, oxidative stress-induced graft failure due to an insufficient …

Long-term graft survival is an ongoing challenge in the field of islet transplantation. With the
growing demand for transplantable organs, therapies to improve organ quality and reduce …

This study aimed to assess the global mapping risk of human islet isolation, using a failure
mode and effect analysis (FMEA), and highlight the impact of quality assurance procedures …

Islet cell transplantation (IT) is a proven therapy in preventing severe hypoglycemia and
restoring insulin independence for the subgroups of patients with type 1 diabetes and …

Clinical islet transplantation was first realized over four decades ago at the University of
Minnesota. Autologous islet transplantation is now widely recognized as a treatment to …

Engineering 3-dimensional (3D), vascularised tissues for therapeutic applications, such as
the testing of chemo-therapeutic drugs or organ replacement, remains a major challenge in …

Islet transplantation is an available option to treat brittle type 1 diabetes and to prevent
pancreatogenic diabetes. Despite the remarkable improvements performed in the field, the …

The International Diabetes Federation estimates 415 million people have diabetes
worldwide, and this number is expected to increase to 642 million by 2040 (1). These …

Islet cell transplantation is an effective method to treat type 1 diabetes mellitus, however,
significant barriers currently exist preventing its implementation as the gold standard …

Abstract Ⅰ 型糖尿病最显著的特征是β 细胞的减少缺失, 因此带来一系列的并发症,
越来越多的患者深受其害. β 细胞作为自身免疫靶点, 最终在炎性介质的诱导下被巨噬细胞和T …