High-mobility group box 1 (HMGB1) can act as a structural protein of the chromatin and at
the same time as a mediator of the immune system. Its high correlation with the graft …

Efficient and consistent cryopreservation of human islets would be a useful tool in
generating islet biobanks for transplantation and research uses. However, current islet …

Standardized islet characterization assays that can provide results in a timely manner are
essential for successful islet cell transplantation. A critical component of islet cell quality is β …

Abbreviations α-gal α-galactose-1, 3-galactose ADP Adenosine-diphosphate Alg/MC
Alginate/methylcellulose blend ATP Adenosine-triphosphate BSA Bovine serum albumin …

Introduction: Type 1 diabetes (T1D) is a disorder of the endocrine system due to the loss of
pancreatic beta cells by autoimmune attacks. T1D patients require lifetime treatment of …

In the last 20 years, the number of patients with diabetes increased almost 3 times and
continued to grow. The absence of a cure and meticulous life-long therapy that consists of …

The encapsulation of pancreatic islets in hydrogels is of topical interest for its potential for
treatment of type-1 diabetes. Clinical investigations have demonstrated only partial success …

No. of pages in text.(138) The overarching goal of this dissertation is to engineer cell culture
platforms that recapitulate dynamic in vivo microenvironments and enable functional …

Despite increasing experience with islet allotransplantation for type 1 diabetes worldwide,
outcomes remain variable and unpredictable. Mesenchymal stem cells (MSCs) have been …

In the pancreas, extracellular matrix (ECM) components play an import role in providing
mechanical and physiological support, and also contribute to the function of islets. These …