In the early nineties, few years before the birth of Europace, the clinical and scientific world
of familial arrhythmogenic conditions was revolutionized by the identification of the first …

Thoracic aortic aneurysm (TAA) is a localized or diffuse dilatation of the thoracic aortas, and
causes many sudden deaths each year worldwide. However, there is no effective …

Sarcopenia is characterized of muscle mass loss and functional decline in elder individuals
which severely affects human physical activity, metabolic homeostasis, and life quality …

Inherited cardiac arrhythmias are a group of genetic diseases predisposing to sudden
cardiac arrest, mainly resulting from variants in genes encoding cardiac ion channels or …

In cardiomyocytes, the rapid depolarisation of the membrane potential is mediated by the α‐
subunit of the cardiac voltage‐gated Na+ channel (NaV1. 5), encoded by the gene SCN5A …

Methods to augment Na+ current in cardiomyocytes hold potential for the treatment of
various cardiac arrhythmias involving conduction slowing. Because the gene coding cardiac …

Trafficking protein particle (TRAPP) is well reported to play a role in the trafficking of protein
products within the Golgi and endoplasmic reticulum. Dysfunction in TRAPP has been …

BACKGROUND: Andersen-Tawil syndrome type 1 is a rare heritable disease caused by
mutations in the gene coding the strong inwardly rectifying K+ channel Kir2. 1. The …

Simple Summary Currently, rodents and pigs are the primary disease models used in
cardiovascular research. Generally, larger animals that are more closely related to humans …

Over the last decades, the relevance of genetics in cardiovascular diseases has expanded,
especially in the context of cardiomyopathies. Its relevance extends to the management of …