The molecular and physical information coded within the extracellular milieu is informing the
development of a new generation of biomaterials for tissue engineering. Several powerful …

Glycosaminoglycans (GAGs) as one major part of the glycocalyx are involved in many
essential biological cell processes, as well as in many courses of diseases. Because of the …

Glycans are key participants in biological processes ranging from reproduction to cellular
communication to infection. Revealing glycan roles and the underlying molecular …

Deep understanding of the structure–property relationships of polysaccharide derivatives
depends on the ability to control the position of the substituents around the monosaccharide …

Graft-through ring-opening metathesis polymerization (ROMP) using ruthenium N-
heterocyclic carbene catalysts has enabled the synthesis of bottle-brush polymers with …

Cellular carbohydrates or glycans are critical mediators of biological function. Their
remarkably diverse structures and varied activities present exciting opportunities for …

The beginning of the 20 th century marked the dawn of modern medicine with glycan-based
therapies at the forefront. However, glycans quickly became overshadowed as DNA-and …

A robust platform for facile defined glycan synthesis does not exist. Yet the need for such
technology has never been greater as researchers seek to understand the full scope of …

Glycosaminoglycans (GAGs) are abundant, ubiquitous carbohydrates in biology, yet their
structural complexity has limited an understanding of their biological roles and structure …

Heparin is a naturally occurring, highly sulfated polysaccharide that plays a critical role in a
range of different biological processes. Therapeutically, it is mostly commonly used as an …