Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …

Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

Although p53-mediated cell-cycle arrest, senescence and apoptosis serve as critical barriers
to cancer development, emerging evidence suggests that the metabolic activities of p53 are …

The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many
human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour …

Tumor suppressor p53 plays a central role in tumor suppression. p53 is the most frequently
mutated gene in human cancer, and over half of human cancers contain p53 mutations …

The tumour suppressor p53 is the most frequently mutated gene in human cancer, with more
than half of all human tumours carrying mutations in this particular gene. Intense efforts to …

Stapled α− helical peptides have emerged as a promising new modality for a wide range of
therapeutic targets. Here, we report a potent and selective dual inhibitor of MDM2 and …

Thirty years ago p53 was discovered as a cellular partner of simian virus 40 large T-antigen,
the oncoprotein of this tumour virus. The first decade of p53 research saw the cloning of p53 …

Currently, around 11 million people are living with a tumour that contains an inactivating
mutation of TP53 (the human gene that encodes p53) and another 11 million have tumours …

The transcription factor, p53, is critical for many important cellular functions involved in
genome integrity, including cell cycle control, DNA damage response, and apoptosis …