One of the joys of participating in biochemical research is being able to observe first hand
the unexpected paradigm shifts that take place in science as surprising new findings are …

We present edition VIII of the genetic map of Salmonella typhimurium LT2. We list a total of
1,159 genes, 1,080 of which have been located on the circular chromosome and 29 of which …

The 1.85 A crystal structure of endonuclease III, combined with mutational analysis,
suggests the structural basis for the DNA binding and catalytic activity of the enzyme. Helix …

MutY, like many DNA base excision repair enzymes, contains a [4Fe4S] 2+ cluster of
undetermined function. Electrochemical studies of MutY bound to a DNA-modified gold …

A protein homologous to the Escherichia coli MutY protein, referred to as MYH, has been
identified in nuclear extracts of calf thymus and human HeLa cells. Western blot …

DNA charge transport (CT) chemistry provides a route to carry out oxidative DNA damage
from a distance in a reaction that is sensitive to DNA mismatches and lesions. Here, DNA …

The genes coding for the translation factor EF-Tu, tufAandtufBare separated by over 700 kb
on the circular chromosome ofSalmonella typhimurium. The coding regions of these genes …

Patients with primary biliary cirrhosis (PBC) frequently have autoantibodies against a 210-
kD integral glycoprotein of the nuclear envelope pore membrane. This protein, termed …

Proteolysis of MutY with trypsin indicated that this DNA mismatch repair enzyme could exist
as two modules and that the N-terminal domain (Met1− Lys225), designated as p26, could …

Escherichia coli MutY protein cleaves A/G-or A/7, 8-dihydro-8-oxo-guanine (A/GO)-
containing DNA on the A-strand by N-glycosylase and apurinic/apyrimidinic endonuclease …