Repeated, intense use of muscles leads to a decline in performance known as muscle
fatigue. Many muscle properties change during fatigue including the action potential …

The shape of the force-velocity (FV) relationship has important implications for different
aspects of muscle physiology, such as muscle efficiency and fatigue, the understanding of …

Variants in> 12 genes encoding sarcomeric proteins can cause various cardiomyopathies.
The two most common are hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy …

Contraction of both skeletal muscle and the heart is thought to be controlled by a calcium-
dependent structural change in the actin-containing thin filaments, which permits the binding …

The quality of genetically encoded calcium indicators (GECIs) has improved dramatically in
recent years, but high-performing ratiometric indicators are still rare. Here we describe a …

Glomerular podocytes are highly specialized cells with a complex cytoarchitecture. Their
most prominent features are interdigitated foot processes with filtration slits in between …

Mensch-erklärt Wie entsteht Durst? Warum brauchen wir Schlaf? Weshalb kommen wir
außer Atem? In der Physiologie lernen Sie, wie der Mensch „funktioniert “. Von der Atmung …

Here we develop a minimal model of the cell actomyosin cortex by forming a quasi-2D cross-
linked filamentous actin (F-actin) network adhered to a model cell membrane and contracted …

Super-relaxation is a state of muscle thick filaments in which ATP turnover by myosin is
much slower than that of myosin II in solution. This inhibited state, in equilibrium with a faster …

The heart either hypertrophies or dilates in response to familial mutations in genes encoding
sarcomeric proteins, which are responsible for contraction and pumping. These mutations …