Duchenne muscular dystrophy (DMD) is a severe, progressive, and ultimately fatal disease
of skeletal muscle wasting, respiratory insufficiency, and cardiomyopathy. The identification …

Auf den" Schmidt/Thews" war immer schon Verlaß! Mit der 26. Auflage wurde wieder ein
Quantensprung in seiner Erfolgsgeschichte erzielt. Eine ausgefeilte Didaktik erschließt nun …

Every heartbeat relies on cyclical interactions between myosin thick and actin thin filaments
orchestrated by rising and falling Ca2+ levels. Thin filaments are comprised of two actin …

Contraction in striated muscle is initiated by calcium binding to troponin complexes, but it is
now understood that dynamic transition of myosin between resting, ordered OFF states on …

Skeletal muscles cope with a large range of activities, from being able to support the body
weight during long periods of upright standing to perform explosive movements in response …

Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

Force generation in striated muscle is primarily controlled by structural changes in the actin-
containing thin filaments triggered by an increase in intracellular calcium concentration …

BACKGROUND Uterine contractile activity plays an important role in many and varied
reproductive functions including sperm and embryo transport, implantation, menstruation …

Spaceflight (SF) has been shown to cause skeletal muscle atrophy; a loss in force and
power; and, in the first few weeks, a preferential atrophy of extensors over flexors. The …

Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated
with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is …