Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives
Oral colon-specific delivery systems emerged as the main therapeutic cargos by making a
significant impact in the field of modern medicine for local drug delivery in intestinal …
significant impact in the field of modern medicine for local drug delivery in intestinal …
Cellular and molecular therapeutic targets in inflammatory bowel disease—focusing on intestinal barrier function
I Schoultz, ÅV Keita - Cells, 2019 - mdpi.com
The human gut relies on several cellular and molecular mechanisms to allow for an intact
and dynamical intestinal barrier. Normally, only small amounts of luminal content pass the …
and dynamical intestinal barrier. Normally, only small amounts of luminal content pass the …
Outcomes of acute leukemia patients transplanted with naive T cell–depleted stem cell grafts
M Bleakley, S Heimfeld, KR Loeb… - The Journal of …, 2015 - Am Soc Clin Investig
BACKGROUND. Graft-versus-host disease (GVHD) is a major cause of morbidity and
mortality following allogeneic hematopoietic stem cell transplantation (HCT). In mice, naive T …
mortality following allogeneic hematopoietic stem cell transplantation (HCT). In mice, naive T …
Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection
K Burge, A Gunasekaran, J Eckert… - International journal of …, 2019 - mdpi.com
Intestinal inflammatory diseases, such as Crohn's disease, ulcerative colitis, and necrotizing
enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of …
enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of …
Exosomes derived from M2b macrophages attenuate DSS-induced colitis
R Yang, Y Liao, L Wang, P He, Y Hu, D Yuan… - Frontiers in …, 2019 - frontiersin.org
Macrophages are commonly classified as M1 macrophages or M2 macrophages. The M2
macrophages are further sub-categorized into M2a, M2b, M2c, and M2d subtypes. The M2a …
macrophages are further sub-categorized into M2a, M2b, M2c, and M2d subtypes. The M2a …
The effect of various doses of oral vitamin D3 supplementation on gut microbiota in healthy adults: a randomized, double-blinded, dose-response study
N Charoenngam, A Shirvani, TA Kalajian… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: To investigate the effects of vitamin D3 supplementation on gut microbiota.
Patients and Methods: Twenty adults with vitamin D insufficiency/deficiency [25 (OH) D< 30 …
Patients and Methods: Twenty adults with vitamin D insufficiency/deficiency [25 (OH) D< 30 …
[HTML][HTML] Role of regulatory T cell in the pathogenesis of inflammatory bowel disease
A Yamada, R Arakaki, M Saito… - World journal of …, 2016 - ncbi.nlm.nih.gov
Regulatory T (T reg) cells play key roles in various immune responses. For example, T reg
cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), which …
cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), which …
AHR activation is protective against colitis driven by T cells in humanized mice
JA Goettel, R Gandhi, JE Kenison, A Yeste… - Cell reports, 2016 - cell.com
Existing therapies for inflammatory bowel disease that are based on broad suppression of
inflammation result in variable clinical benefit and unwanted side effects. A potential …
inflammation result in variable clinical benefit and unwanted side effects. A potential …
Mesenchymal stem cells for perianal Crohn's disease
Perianal fistulizing Crohn's disease (PFCD) is associated with significant morbidity and
might negatively impact the quality of life of CD patients. In the last two decades, the …
might negatively impact the quality of life of CD patients. In the last two decades, the …
Microbiome and colorectal cancer: Unraveling host-microbiota interactions in colitis-associated colorectal cancer development
Dysbiosis of gut microbiota occurs in many human chronic immune-mediated diseases,
such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) …
such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) …