Bioresponsive drug delivery systems in intestinal inflammation: State-of-the-art and future perspectives

NG Kotla, S Rana, G Sivaraman, O Sunnapu… - Advanced drug delivery …, 2019 - Elsevier
Oral colon-specific delivery systems emerged as the main therapeutic cargos by making a
significant impact in the field of modern medicine for local drug delivery in intestinal …

Cellular and molecular therapeutic targets in inflammatory bowel disease—focusing on intestinal barrier function

I Schoultz, ÅV Keita - Cells, 2019 - mdpi.com
The human gut relies on several cellular and molecular mechanisms to allow for an intact
and dynamical intestinal barrier. Normally, only small amounts of luminal content pass the …

Outcomes of acute leukemia patients transplanted with naive T cell–depleted stem cell grafts

M Bleakley, S Heimfeld, KR Loeb… - The Journal of …, 2015 - Am Soc Clin Investig
BACKGROUND. Graft-versus-host disease (GVHD) is a major cause of morbidity and
mortality following allogeneic hematopoietic stem cell transplantation (HCT). In mice, naive T …

Curcumin and intestinal inflammatory diseases: molecular mechanisms of protection

K Burge, A Gunasekaran, J Eckert… - International journal of …, 2019 - mdpi.com
Intestinal inflammatory diseases, such as Crohn's disease, ulcerative colitis, and necrotizing
enterocolitis, are becoming increasingly prevalent. While knowledge of the pathogenesis of …

Exosomes derived from M2b macrophages attenuate DSS-induced colitis

R Yang, Y Liao, L Wang, P He, Y Hu, D Yuan… - Frontiers in …, 2019 - frontiersin.org
Macrophages are commonly classified as M1 macrophages or M2 macrophages. The M2
macrophages are further sub-categorized into M2a, M2b, M2c, and M2d subtypes. The M2a …

The effect of various doses of oral vitamin D3 supplementation on gut microbiota in healthy adults: a randomized, double-blinded, dose-response study

N Charoenngam, A Shirvani, TA Kalajian… - Anticancer …, 2020 - ar.iiarjournals.org
Background/Aim: To investigate the effects of vitamin D3 supplementation on gut microbiota.
Patients and Methods: Twenty adults with vitamin D insufficiency/deficiency [25 (OH) D< 30 …

[HTML][HTML] Role of regulatory T cell in the pathogenesis of inflammatory bowel disease

A Yamada, R Arakaki, M Saito… - World journal of …, 2016 - ncbi.nlm.nih.gov
Regulatory T (T reg) cells play key roles in various immune responses. For example, T reg
cells contribute to the complex pathogenesis of inflammatory bowel disease (IBD), which …

AHR activation is protective against colitis driven by T cells in humanized mice

JA Goettel, R Gandhi, JE Kenison, A Yeste… - Cell reports, 2016 - cell.com
Existing therapies for inflammatory bowel disease that are based on broad suppression of
inflammation result in variable clinical benefit and unwanted side effects. A potential …

Mesenchymal stem cells for perianal Crohn's disease

M Carvello, A Lightner, T Yamamoto, PG Kotze… - Cells, 2019 - mdpi.com
Perianal fistulizing Crohn's disease (PFCD) is associated with significant morbidity and
might negatively impact the quality of life of CD patients. In the last two decades, the …

Microbiome and colorectal cancer: Unraveling host-microbiota interactions in colitis-associated colorectal cancer development

M Kang, A Martin - Seminars in immunology, 2017 - Elsevier
Dysbiosis of gut microbiota occurs in many human chronic immune-mediated diseases,
such as inflammatory bowel disease (IBD) and colitis-associated colorectal cancer (CAC) …