An overview of the innate and adaptive immune system in inflammatory bowel disease

MC Choy, K Visvanathan… - Inflammatory bowel …, 2017 - academic.oup.com
Inflammatory bowel diseases (IBDs) are thought to develop as a result of complex
interactions between host genetics, the immune system and the environment including the …

ECM1 is an essential factor for the determination of M1 macrophage polarization in IBD in response to LPS stimulation

Y Zhang, X Li, Z Luo, L Ma, S Zhu… - Proceedings of the …, 2020 - National Acad Sciences
Inflammatory bowel disease (IBD) comprises chronic relapsing disorders of the
gastrointestinal tract characterized pathologically by intestinal inflammation and epithelial …

[HTML][HTML] Translating treg therapy for inflammatory bowel disease in humanized mice

S Negi, S Saini, N Tandel, K Sahu, RPN Mishra… - Cells, 2021 - mdpi.com
Crohn's disease and ulcerative colitis, two major forms of inflammatory bowel disease (IBD)
in humans, afflicted in genetically predisposed individuals due to dysregulated immune …

The role of all-trans retinoic acid in the biology of Foxp3+ regulatory T cells

ZM Liu, KP Wang, J Ma, S Guo Zheng - Cellular & molecular …, 2015 - nature.com
Regulatory T (Treg) cells are necessary for immune system homeostasis and the prevention
of autoimmune diseases. Foxp3 is specifically expressed in Treg cells and plays a key role …

[HTML][HTML] TIGIT as a promising therapeutic target in autoimmune diseases

C Yue, S Gao, S Li, Z Xing, H Qian, Y Hu… - Frontiers in …, 2022 - frontiersin.org
Co-inhibitory receptors (IRs) are molecules that protect host against autoimmune reactions
and maintain peripheral self-tolerance, playing an essential role in maintaining immune …

[HTML][HTML] Bifidobacterium infantis ameliorates chemotherapy-induced intestinal mucositis via regulating T cell immunity in colorectal cancer rats

H Mi, Y Dong, B Zhang, H Wang, CCK Peter… - Cellular Physiology and …, 2017 - karger.com
Background/Aims: Intestinal mucositis (IM) is a commonly encountered side effect in cancer
patients receiving chemotherapy. This study aimed to investigate the effect of …

Live and heat-killed probiotic Lactobacillus casei Lbs2 protects from experimental colitis through Toll-like receptor 2-dependent induction of T-regulatory response

BK Thakur, P Saha, G Banik, DR Saha, S Grover… - International …, 2016 - Elsevier
Inflammatory bowel disease (IBD) is a group of inflammatory disorders of the intestine
caused by dysregulated T-cell mediated immune response against commensal microflora …

Bile acid malabsorption in inflammatory bowel disease

L Vítek - Inflammatory bowel diseases, 2015 - academic.oup.com
Bile acid malabsorption (BAM) is a common but an underestimated and often neglected sign
of inflammatory bowel diseases (IBDs), especially those affecting the distal ileum. Clinically …

[HTML][HTML] Heterogeneity across the murine small and large intestine

R Bowcutt, R Forman, M Glymenaki… - World journal of …, 2014 - ncbi.nlm.nih.gov
The small and large intestine of the gastrointestinal tract (GIT) have evolved to have discrete
functions with distinct anatomies and immune cell composition. The importance of these …

IL-10+ regulatory B cells are enriched in cord blood and may protect against cGVHD after cord blood transplantation

A Sarvaria, R Basar, RS Mehta, H Shaim… - Blood, The Journal …, 2016 - ashpublications.org
Cord blood (CB) offers a number of advantages over other sources of hematopoietic stem
cells, including a lower rate of chronic graft-versus-host disease (cGVHD) in the presence of …