Oleanolic acid ameliorates dextran sodium sulfate-induced colitis in mice by restoring the balance of Th17/Treg cells and inhibiting NF-κB signaling pathway

GD Kang, S Lim, DH Kim - International Immunopharmacology, 2015 - Elsevier
In a preliminary experiment, it was found that oleanolic acid (OA), which is widely distributed
in food and medicinal plants, inhibited interleukin (IL)-6/tumor growth factor beta-induced …

Estrogen receptor β activation ameliorates DSS-induced chronic colitis by inhibiting inflammation and promoting Treg differentiation

D Guo, X Liu, C Zeng, L Cheng, G Song, X Hou… - International …, 2019 - Elsevier
Estrogen receptor (ER) β activation has anti-inflammatory activity. However, its effect on the
development of inflammatory bowel disease (IBD) and the underlying mechanism have not …

[HTML][HTML] ABX464 (obefazimod) upregulates miR-124 to reduce proinflammatory markers in inflammatory bowel diseases

C Apolit, N Campos, A Vautrin… - Clinical and …, 2023 - journals.lww.com
Advanced therapies have transformed the treatment of inflammatory bowel disease;
however, many patients fail to respond, highlighting the need for therapies tailored to the …

Immunotherapy in inflammatory bowel disease: novel and emerging treatments

I Catalan-Serra, Ø Brenna - Human vaccines & …, 2018 - Taylor & Francis
Inflammatory bowel disease (IBD) is a chronic disabling inflammatory process that affects
young individuals, with growing incidence. The etiopathogenesis of IBD remains poorly …

[HTML][HTML] Monosexual Cercariae of Schistosoma japonicum Infection Protects Against DSS-Induced Colitis by Shifting the Th1/Th2 Balance and Modulating the Gut …

H Zhou, X Zeng, D Sun, Z Chen, W Chen… - Frontiers in …, 2021 - frontiersin.org
Inflammatory bowel disease (IBD)-related inflammation is closely associated with the
initiation and progression of colorectal cancer. IBD is generally treated with 5-aminosalicylic …

The role of IL-33/ST2 signaling in the tumor microenvironment and Treg immunotherapy

S Lei, J Jin, X Zhao, L Zhou, G Qi… - … Biology and Medicine, 2022 - journals.sagepub.com
Interleukin (IL)-33 is a tissue-derived nuclear cytokine belonging to the IL-1 family.
Stimulation-2 (ST2) is the only known IL-33 receptor. ST2 signals mostly on immune cells …

Lactobacillus plantarum NCU1125 mitigates intestinal barrier injury induced by cyclophosphamide in mice

F Min, J Hu, Y Zhong, T Huang, Y Huang, S Nie… - Food Bioscience, 2023 - Elsevier
A previous study demonstrated that Lactobacillus (L.) plantarum NCU1125, derived from
fermented Nanfeng mandarin, survived in vitro simulated gastrointestinal digestion …

IL‐33 protects mice against DSS‐induced chronic colitis by increasing both regulatory B cell and regulatory T cell responses as well as decreasing Th17 cell response

J Zhu, Y Xu, J Zhao, X Li, X Meng… - Journal of …, 2018 - Wiley Online Library
Background. Previously, we have reported that IL‐33 functioned as a protective modulator in
dextran sulfate sodium‐(DSS‐) induced chronic colitis by suppressing Th17 cell response in …

Enhancement of circulating and intestinal T regulatory cells and their expression of helios and neuropilin-1 in children with inflammatory bowel disease

K Sznurkowska, J Luty, E Bryl… - Journal of …, 2020 - Taylor & Francis
Background/Aims The proportions of intestinal and peripheral regulatory T cells (Tregs) in
pediatric inflammatory bowel disease (IBD) were poorly investigated, as well as different …

Regulatory T cells induce transplant immune tolerance

J Lu, P Li, X Du, Y Liu, B Zhang, F Qi - Transplant Immunology, 2021 - Elsevier
Organ transplantation is the preferred treatment option for end-stage organ failure. Although
immunosuppressants are effective for preventing the occurrence of acute rejection, they also …