Neomangiferin modulates the Th17/Treg balance and ameliorates colitis in mice

SM Lim, GD Kang, JJ Jeong, HS Choi, DH Kim - Phytomedicine, 2016 - Elsevier
Abstract Background Anemarrhena asphodeloides (Liliaceae family) and Mangifera indica
L.(Anacardiaceae family) contain neomangiferin as the main active constituent and have …

Blood and intestine eQTLs from an anti-TNF-resistant Crohn's disease cohort inform IBD genetic association loci

AF Di Narzo, LA Peters, C Argmann… - Clinical and …, 2016 - journals.lww.com
OBJECTIVES: Genome-wide association studies (GWAS) have identified loci reproducibly
associated with inflammatory bowel disease (IBD) and other immune-mediated diseases; …

Oral immune therapy: targeting the systemic immune system via the gut immune system for the treatment of inflammatory bowel disease

Y Ilan - Clinical & translational immunology, 2016 - Wiley Online Library
Inflammatory bowel diseases (IBD) are associated with an altered systemic immune
response leading to inflammation‐mediated damage to the gut and other organs. Oral …

[HTML][HTML] Bifidobacterium infantis attenuates colitis by regulating T cell subset responses

L Zuo, KT Yuan, L Yu, QH Meng… - World Journal of …, 2014 - ncbi.nlm.nih.gov
AIM: to investigate the effect of Bifidobacterium infantis (B. infantis) on the T cell subsets and
in attenuating the severity of experimental colitis in mice. METHODS: Normal BALB/c mice …

Ocotillol, a majonoside R2 metabolite, ameliorates 2, 4, 6-trinitrobenzenesulfonic acid-induced colitis in mice by restoring the balance of Th17/Treg cells

SY Lee, JJ Jeong, THV Le, SH Eun… - Journal of agricultural …, 2015 - ACS Publications
In a preliminary experiment, majonoside R2 (MR2), isolated from Vietnamese ginseng
(Panax vietnamensis Ha et Grushv.), inhibited differentiation to Th17 cells and was …

Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis

S Reißig, Y Tang, A Nikolaev, K Gerlach, C Wolf… - Nature …, 2017 - nature.com
Bcl-3 is an atypical NF-κB family member that regulates NF-κB-dependent gene expression
in effector T cells, but a cell-intrinsic function in regulatory T (Treg) cells and colitis is not …

Targeting the intestinal circadian clock by meal timing ameliorates gastrointestinal inflammation

Y Niu, M Heddes, B Altaha, M Birkner… - Cellular & Molecular …, 2024 - nature.com
The expression of clock genes has been observed to be impaired in biopsies from patients
with inflammatory bowel disease (IBD). Disruption of circadian rhythms, which occurs in shift …

Stem cells in treatment of crohn's disease: Recent advances and future directions

TC Mohammadi, K Jazi, A Bolouriyan… - Transplant …, 2023 - Elsevier
Background and aim Crohn's disease (CD) is an inflammatory bowel disease that can affect
any part of the intestine. There is currently no recognized cure for CD because its cause is …

Thermally engineered MSC-derived extracellular vesicles ameliorate colitis in mice by restoring the imbalanced Th17/Treg cell ratio

D Tang, M Liu, S Gao, H Sun, Y Peng, Y Li… - International …, 2023 - Elsevier
Mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs) have garnered extensive
interest for their immunomodulatory properties in immune-mediated inflammatory diseases …

Anti-inflammatory effect of IL-37-producing T-cell population in DSS-induced chronic inflammatory bowel disease in mice

Z Chen, S Wang, L Li, Z Huang, K Ma - International Journal of Molecular …, 2018 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic inflammatory disease that is thought to arise
in part from abnormal adaptive immune responses against intestinal microbiota. T …