[HTML][HTML] Prostate cancer genetic risk and associated aggressive disease in men of African ancestry
PXY Soh, N Mmekwa, DC Petersen, K Gheybi… - Nature …, 2023 - nature.com
African ancestry is a significant risk factor for prostate cancer and advanced disease. Yet,
genetic studies have largely been conducted outside the context of Sub-Saharan Africa …
genetic studies have largely been conducted outside the context of Sub-Saharan Africa …
[HTML][HTML] The impact of telomere length on prostate cancer aggressiveness, genomic instability and health disparities
R Huang, MSR Bornman, PD Stricker, I Simoni Brum… - Scientific Reports, 2024 - nature.com
The telomere repetitive TTAGGG motif at the ends of chromosomes, serves to preserve
genomic integrity and chromosomal stability. In turn, genomic instability is a hallmark of …
genomic integrity and chromosomal stability. In turn, genomic instability is a hallmark of …
[HTML][HTML] ERBB3 Overexpression is Enriched in Diverse Patient Populations with Castration-sensitive Prostate Cancer and is Associated with a Unique AR Activity …
JE Vellky, BJ Kirkpatrick, LC Gutgesell, M Morales… - Clinical Cancer …, 2024 - AACR
Purpose: Despite successful clinical management of castration-sensitive prostate cancer
(CSPC), the 5-year survival rate for men with castration-resistant prostate cancer is only …
(CSPC), the 5-year survival rate for men with castration-resistant prostate cancer is only …
Rare pathogenic structural variants show potential to enhance prostate cancer germline testing for African men
Prostate cancer (PCa) is highly heritable, with men of African ancestry at greatest risk and
associated lethality. Lack of representation in genomic data means germline testing …
associated lethality. Lack of representation in genomic data means germline testing …
Associating serum testosterone levels with African ancestral prostate cancer health disparities
MT Lebelo, N Mmekwa, W Jaratlerdsiri… - 2024 - researchsquare.com
Serum testosterone levels decrease in the aging male, while the risk for prostate cancer
(PCa) increases concomitantly. Higher levels in younger men have been linked with racially …
(PCa) increases concomitantly. Higher levels in younger men have been linked with racially …