Summary Background Prader–Willi syndrome (PWS) children have impaired growth, and
abnormal body composition. Previous 1‐year controlled studies showed improvement of …

Insulin‐like growth factor‐I (IGF‐I) has mitogenic and anti‐apoptotic effects on breast cancer
cells. Epidemiologic studies have shown that high plasma levels of IGF‐I and low levels of …

Poor glycaemic control in type 1 diabetes is associated with elevated serum IGFBP‐1 levels
and reduced rather than elevated serum IGF‐I levels. Increasing age is accompanied by a …

Broad variation in intra-and interspecific life-history traits is largely shaped by resource
limitation and the ensuing allocation trade-offs that animals are forced to make. Insulin-like …

Bone remodeling is a temporally regulated process resulting in the coordinated resorption
and formation of skeletal tissue carried out in basic multicellular units throughout life. 1 …

Objective Growth hormone and its mediator, insulin-like growth factor-1 (IGF-1), have been
suggested to exert gonadotropic actions in both humans and animals. The present study …

Verapamil promotes functional β-cell mass and improves glucose homeostasis in diabetic
mice and humans with type 1 diabetes (T1D). Now, our global proteomics analysis of serum …

Background: Phase III trials of the anti-insulin-like growth factor type 1 receptor (IGF-IR)
antibody figitumumab (F) in unselected non-small-cell lung cancer (NSCLC) patients were …

As IGF-1 is the major factor that affects bone growth, and both osteocalcin and bone-specific
alkaline phosphatase are important markers of bone formation during puberty, there must be …

According to the somatomedin model, growth hormone (GH)-dependent hepatic synthesis is
responsible for maintaining circulating insulin-like growth factor (IGF)-I levels. On the other …