Abstract Context: Regulation of IGF-I activity appears crucial in anorexia nervosa (AN)
during adaptation to chronic starvation as well as during the regenerative processes on …

Pituitary GH secretion is feedback regulated by circulating IGF-I. However, it remains to be
determined whether the feedback control is mediated through circulating free or total IGF-I …

Brain and muscle ARNT-like protein-1 (BMAL-1) is an important component of the cellular
circadian clock. Proteins such as epidermal (EGF) or nerve growth factor (NGF) affect the …

Low circulating levels of adiponectin and high levels of insulin-like growth factor-1 (IGF-1), C-
reactive protein (CRP), and C-peptide have been shown to be related to postmenopausal …

Context Pregnancy-associated plasma protein A2 (PAPPA2) is a protease that cleaves IGF-
binding protein (IGFBP)-3 and IGFBP-5, liberating free IGF-I. Five patients from two families …

Context The rapid pubertal height growth is unique to humans, but why do we have it?
Although the spurt contributes 13% to 15% to the final adult height, we hypothesized that the …

Forty-eight normal full-term Chinese babies (25 boys and 23 girls) were followed up every 2
mo in the first year and every 3 mo during the second year of life for anthropometric …

The GH/IGF1 system, like other endocrine systems, is dynamic and its activity changes with
age and sexual maturation, and is influenced by body composition and other factors. A …

In children with Prader–Willi syndrome (PWS), the standard growth hormone (GH) dose
often results in high immunoreactive IGF-I levels. These high immunoreactive IGF-I levels …

SINCE THE introduction of the somatomedin hypothesis by Daughaday et al.(1) almost a
half-century ago, our understanding of the insulin-like growth factor (IGF) system has …