Objective: Gynecomastia is defined as a benign proliferation of male breast glandular tissue.
Its prevalence during puberty varies between 50-60% and is also common in neonatal and …

Two fundamentally different methods are currently used for the determination of free insulin-
like growth factor-I (IGF-I): ultrafiltration by centrifugation (UF) and direct immunoradiometric …

To determine the effect of acute insulin withdrawal and its subsequent replacement on
components of the insulin-like growth factor (IGF)-1 binding protein system and on …

At least four premature newborn complications have been reported to be associated with
low serum insulin-like growth factor-I (IGF-I) levels: bronchopulmonary dysplasia …

It is known that shorter stature is associated with sensorineural hearing loss; and that
cochlear development is associated with activity of IGF 1, as are many important aspects of …

Understanding the involvement of the insulin-GH-IGF-axis in the different phases of human
growth, development, and metabolism is the key to understanding human pathophysiology …

Free IGF-I by analogy with sex and adrenal steroids and thyroid hormones, may be the
major biologically active hormonal form of IGF-I. Because of methodological difficulties in …

Gonadotropin releasing hormone analogues (GnRHa) have been used for treatment of
central precocious puberty (CPP) for more than 15 years. They are generally considered …

OBJECTIVE Treatment with human recombinant growth hormone has yielded conflicting
results in patients with congestive heart failure. In addition, growth hormone resistance has …

In mammals, the rate of somatic growth is rapid in early postnatal life but then slows with
age, approaching zero as the animal approaches adult body size. To investigate the …