Importance of the field: Piperacillin-tazobactam is a frequently prescribed intravenous
antibiotic for moderate to severe infections used in hospital settings because of its broad …

Introduction: Emerging studies suggest that antibiotic pharmacokinetics (PK) are difficult to
predict in critically ill patients. The high intra-and inter-patient PK variability makes it …

Purpose Risk factors for β-lactam antibiotic underdosing in critically ill patients have not
been described in large-scale studies. The objective of this study was to describe …

Piperacillin-tazobactam (PTZ) is one of the most common antibiotics administered to
hospitalized patients. Its broad activity against gram-negative, gram-positive, and anaerobic …

Piperacillin-tazobactam is often given to infants with severe infection in spite of limited
pharmacokinetics (PK) data. We evaluated piperacillin-tazobactam PK in premature and …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of extended-infusion piperacillin-tazobactam in children hospitalized in …

The study objective was to evaluate the population pharmacokinetics and
pharmacodynamics of piperacillin and tazobactam administered by prolonged infusion in …

Extensively drug-resistant (XDR) Klebsiella pneumoniae is an emerging pathogen in
Singapore. With limited therapeutic options available, combination antibiotics may be the …

Breakpoints are the values used by clinical microbiology laboratories to interpret the results
of antimicrobial susceptibility testing (AST) and classify isolates as susceptible or resistant …

Acute kidney injury (AKI) is a common problem in hospitalized patients and is associated
with significant morbidity and mortality. Two large trials showed no benefit from increased …