This review concerns how cytoplasmic mRNA half-lives are regulated and how mRNA decay
rates influence gene expression. mRNA stability influences gene expression in virtually all …

Regulation of gene expression is essential for the homeostasis of an organism, playing a
pivotal role in cellular proliferation, differentiation, and response to specific stimuli. Multiple …

The adenylate uridylate-rich elements (AREs) mediate the rapid turnover of mRNAs
encoding proteins that regulate cellular growth and body response to exogenous agents …

We isolated a gene from a mouse pituitary cDNA library that encodes a protein highly
homologous to nuclear factor CREB, an activator of cAMP-responsive promoter elements …

The cyclooxygenase (COX)-2 enzyme is responsible for increased prostaglandin formation
in inflammatory states and is the major target of nonsteroidal anti-inflammatory drugs …

We used microarray technology to measure mRNA decay rates in resting and activated T
lymphocytes in order to better understand the role of mRNA decay in regulating gene …

We have cloned the human jun-6 gene and determined its sequence and transforming and
trans-activating activities. jun-6 is less potent than c-jun in transforming and immortalizing …

A considerable number of genes that code for AU-rich mRNAs including cytokines, growth
factors, transcriptional factors, and certain receptors are involved in both chronic …

During the last decade evidence has accumulated that modulation of mRNA stability plays a
central role in cellular homeostasis, including cell differentiation, proliferation and adaptation …

The AU-rich elements (AREs) are among the predominant cis-acting factors that exist
primarily in the 3'untranslated region (3'-UTR) of messenger RNAs (mRNAs) and regulate …