PPARγ activators improve glucose homeostasis by stimulating fatty acid uptake in the adipocytes

G Martin, K Schoonjans, B Staels, J Auwerx - Atherosclerosis, 1998 - Elsevier
It is currently thought that the effects of PPARγ activation on glucose homeostasis may be
due to the effect of this nuclear receptor on the production of adipocyte-derived signalling …

Apolipoprotein C-III and hepatic triglyceride-rich lipoprotein production

Z Yao, Y Wang - Current opinion in lipidology, 2012 - journals.lww.com
The current review summarizes recent experimental evidence for an intrahepatic role of
human apo C-III in promoting mobilization and utilization of triglyceride during VLDL 1 …

ApoC-III ASO promotes tissue LPL activity in the absence of apoE-mediated TRL clearance

B Ramms, S Patel, C Nora, AR Pessentheiner… - Journal of lipid …, 2019 - ASBMB
Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs)
in the circulation and is associated with increased CVD risk. ApoC-III is an apolipoprotein on …

HDL, atherosclerosis, and emerging therapies

A Hafiane, J Genest - Cholesterol, 2013 - Wiley Online Library
This review aims to provide an overview on the properties of high‐density lipoproteins
(HDLs) and their cardioprotective effects. Emergent HDL therapies will be presented in the …

Science behind the cardio-metabolic benefits of omega-3 polyunsaturated fatty acids: biochemical effects vs. clinical outcomes

RN Thota, JJA Ferguson, KA Abbott, CB Dias… - Food & function, 2018 - pubs.rsc.org
Lower incidence of cardiovascular disease (CVD) in the Greenland Inuit, Northern Canada
and Japan has been attributed to their consumption of seafood rich in long chain omega-3 …

Historical perspective: phosphatidylserine and phosphatidylethanolamine from the 1800s to the present

JE Vance - Journal of lipid research, 2018 - ASBMB
This article provides a historical account of the discovery, chemistry, and biochemistry of two
ubiquitous phosphoglycerolipids, phosphatidylserine (PS) and phosphatidylethanolamine …

Modulation of rat liver apolipoprotein gene expression and serum lipid levels by tetradecylthioacetic acid (TTA) via PPARα activation

E Raspé, L Madsen, AM Lefebvre, I Leitersdorf… - Journal of lipid …, 1999 - ASBMB
3-Thia fatty acids are modified fatty acids that promote hepatic peroxisome proliferation and
decrease serum triacylglycerol, cholesterol and free fatty acid levels in rats. In vivo …

Angptl3-null mice show low plasma lipid concentrations by enhanced lipoprotein lipase activity

K Fujimoto, R Koishi, T Shimizugawa… - Experimental animals, 2006 - jstage.jst.go.jp
Angiopoietin-like 3 (ANGPTL3) is a secreted protein with both angiogenesis and lipid
metabolism functions. We generated knockout mice that failed to express the Angptl3 gene …

A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient mice

Y Ando, T Shimizugawa, S Takeshita, M Ono… - Journal of lipid …, 2003 - ASBMB
KK/Snk mice (previously KK/San) possessing a recessive mutation (hypl) of the angiopoietin-
like 3 (Angptl3) gene homozygously exhibit a marked reduction of VLDL due to the …

Apolipoprotein CIII deficiency protects against atherosclerosis in knockout rabbits

H Yan, M Niimi, F Matsuhisa, H Zhou… - … , and vascular biology, 2020 - Am Heart Assoc
Objective: Apo (apolipoprotein) CIII mediates the metabolism of triglyceride (TG)-rich
lipoproteins. High levels of plasma apoCIII are positively correlated with the plasma TG …