Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix,
where they interact with a plethora of proteins involved in lipid homeostasis and …

Peroxisome proliferator-activated receptor (PPAR) γ coactivator-1β (PGC-1β) is a
transcriptional coactivator that induces hypertriglyceridemia in response to dietary fats …

We previously showed that human apoC-III expression in transgenic mice causes
hypertriglyceridemia due to the accumulation of enlarged very low density lipoprotein …

The atherogenicity theory for triglyceride-rich lipoproteins (TRLs; VLDL+ intermediate
density lipoprotein) generally cites the action of apolipoprotein C-III (apoC-III), a component …

Apolipoprotein (apo) C-III and apoE play a central role in controlling the plasma metabolism
of triglyceride-rich lipoproteins (TRL). We have investigated the plasma kinetics of total, very …

Dietary fat is an important mediator of atherosclerosis and obesity. Despite its importance in
mediating metabolic disease, there is still much unknown about dietary fat absorption in the …

Acylation-stimulating protein (ASP) acts as a paracrine signal to increase triglyceride
synthesis in adipocytes. ASP administration results in more rapid postprandial lipid …

APOA5 as the source of the association signal. 21 However, there are complex patterns of
linkage disequilibrium between common polymorphisms of APOA5 and APOC3, and it …

Chronic renal insufficiency (CRI) is associated with a characteristic dyslipidemia. Findings in
children with CRI largely parallel those in adults. Moderate hypertriglyceridemia, increased …

Abstract Apolipoprotein C3 (apoC3) and apolipoprotein A5 (apoA5), encoded by
APOA1/C3/A4/A5 gene cluster, are two critical regulators of plasma triglyceride (TG) …