[HTML][HTML] Advances in understanding the role of NRF2 in liver pathophysiology and its relationship with hepatic-specific Cyclooxygenase-2 expression
M Fuertes-Agudo, M Luque-Tévar, C Cucarella… - Antioxidants, 2023 - mdpi.com
Oxidative stress and inflammation play an important role in the pathophysiological changes
of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor …
of liver diseases. Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor …
[HTML][HTML] Alcohol consumption and risk of liver fibrosis in people living with HIV: A systematic review and meta-analysis
H Lyu, H Tang, Y Liang, S Huang, Y Wang… - Frontiers in …, 2022 - frontiersin.org
Objectives It is unclear if a high level of alcohol consumption is a risk factor for liver fibrosis
for people living with HIV (PLWH). This study systematically summarizes the risk relationship …
for people living with HIV (PLWH). This study systematically summarizes the risk relationship …
[HTML][HTML] Mulberrin confers protection against hepatic fibrosis by Trim31/Nrf2 signaling
C Ge, J Tan, D Lou, L Zhu, Z Zhong, X Dai, Y Sun… - Redox biology, 2022 - Elsevier
Mulberrin (Mul) is a key component of the traditional Chinese medicine Romulus Mori with
various biological functions. However, the effects of Mul on liver fibrosis have not been …
various biological functions. However, the effects of Mul on liver fibrosis have not been …
[HTML][HTML] E Se tea extract ameliorates CCl4 induced liver fibrosis via regulating Nrf2/NF-κB/TGF-β1/Smad pathway
Z Wang, P Sun, T Zhao, J Cao, Y Liu, A Khan, W Zhou… - Phytomedicine, 2023 - Elsevier
Background Liver fibrosis is a crucial progress to deteriorate liver disease. E Se tea (ES) is
an ethnic herbal tea in China that has various biological activities for human beings …
an ethnic herbal tea in China that has various biological activities for human beings …
[HTML][HTML] Angelica polysaccharide antagonizes 5-FU-induced oxidative stress injury to reduce apoptosis in the liver through Nrf2 pathway
D Zeng, Y Wang, Y Chen, D Li, G Li, H Xiao… - Frontiers in …, 2021 - frontiersin.org
Oxidative stress induced by chemotherapeutic agents causes hepatotoxicity. 5-Fluorouracil
(5-FU) has been found to have a variety of side effects, but its toxic effect on the liver and the …
(5-FU) has been found to have a variety of side effects, but its toxic effect on the liver and the …
[HTML][HTML] 4-OI attenuates carbon tetrachloride-induced hepatic injury via regulating oxidative stress and the inflammatory response
R Li, W Yang, Y Yin, X Ma, P Zhang… - Frontiers in pharmacology, 2021 - frontiersin.org
The liver is an important metabolic organ, and acute liver injury (ALI) is potentially lethal.
Itaconate, a metabolic intermediate from the tricarboxylic acid cycle, showed emerging anti …
Itaconate, a metabolic intermediate from the tricarboxylic acid cycle, showed emerging anti …
[HTML][HTML] Alpinetin exerts anti-inflammatory, anti-oxidative and anti-angiogenic effects through activating the Nrf2 pathway and inhibiting NLRP3 pathway in carbon …
Z Zhu, R Hu, J Li, X Xing, J Chen, Q Zhou… - International …, 2021 - Elsevier
Alpinetin is the major active ingredient of Alpiniakatsumadai Hayata. As a kind of novel plant-
derived flavonoid, alpinetin has shown potent hepatoprotective effect against many liver …
derived flavonoid, alpinetin has shown potent hepatoprotective effect against many liver …
[HTML][HTML] Theaflavine inhibits hepatic stellate cell activation by modulating the PKA/LKB1/AMPK/GSK3β cascade and subsequently enhancing Nrf2 signaling
G Shu, H Sun, T Zhang, A Zhu, X Lei, C Wang… - European Journal of …, 2023 - Elsevier
Activation of hepatic stellate cells (HSCs) constitutes a crucial etiological factor leading to
liver fibrosis. Theaflavine (TF) is a characteristic bioactive compound in fermented tea. Here …
liver fibrosis. Theaflavine (TF) is a characteristic bioactive compound in fermented tea. Here …
[HTML][HTML] Puerarin attenuates cadmium-induced hepatic lipid metabolism disorder by inhibiting oxidative stress and inflammation in mice
XM Wan, J Chen, M Wang, C Zheng, XL Zhou - Journal of inorganic …, 2021 - Elsevier
Cadmium (Cd) is a common environmental pollutant with known toxic effects on the liver.
Puerarin (PU), a natural flavonoid, has been shown to exert protective effect in numerous …
Puerarin (PU), a natural flavonoid, has been shown to exert protective effect in numerous …
[HTML][HTML] Roles of NRF2 in fibrotic diseases: from mechanisms to therapeutic approaches
W Hao, M Li, Q Cai, S Wu, X Li, Q He, Y Hu - Frontiers in Physiology, 2022 - frontiersin.org
Fibrosis is a persistent inflammatory response that causes scarring and tissue sclerosis by
stimulating myofibroblasts to create significant quantities of extracellular matrix protein …
stimulating myofibroblasts to create significant quantities of extracellular matrix protein …