Mitochondria are dynamic organelles that continually undergo fusion and fission. These
opposing processes work in concert to maintain the shape, size, and number of …

Cristae, the organized invaginations of the mitochondrial inner membrane, respond
structurally to the energetic demands of the cell. The mechanism by which these dynamic …

The importance of mitochondrial dynamics, the physiological process of mitochondrial fusion
and fission, in regulating diverse cellular functions and cellular fitness has been well …

Mitochondria perform diverse yet interconnected functions, producing ATP and many
biosynthetic intermediates while also contributing to cellular stress responses such as …

A mechanistic understanding of how mitochondrial dysfunction contributes to cell growth
and tumorigenesis is emerging beyond Warburg as an area of research that is under …

Apoptosis is a process of programmed cell death that serves as a major mechanism for the
precise regulation of cell numbers, and as a defense mechanism to remove unwanted and …

Background—Whether alterations in mitochondrial morphology affect the susceptibility of the
heart to ischemia/reperfusion injury is unknown. We hypothesized that modulating …

Mitochondrial dynamics and mitophagy are recognized as two critical processes underlying
mitochondrial homeostasis. Morphological and bioenergetic characterization of the life cycle …

Endoplasmic reticulum (ER) stress is transmitted to mitochondria and is associated with
pathologic mitochondrial dysfunction in diverse diseases. The PERK arm of the unfolded …

Mitochondria are dynamic organelles that undergo membrane remodeling events in
response to metabolic alterations to generate an adequate mitochondrial network. Here, we …