The dynamic network of mitochondria fragments under stress allowing the segregation of
damaged mitochondria and, in case of persistent damage, their selective removal by …

Mitochondrial fusion requires the coordinated fusion of the outer and inner membranes.
Three large GTPases—OPA1 and the mitofusins Mfn1 and Mfn2—are essential for the …

Mitochondrial dysfunction is linked to apoptosis, aging, cancer, and a number of
neurodegenerative and muscular disorders. The interplay between mitophagy and …

The liver is a major organ that coordinates the metabolic flexibility of the whole body, which
is characterized by the ability to adapt dynamically in response to fluctuations in energy …

Neuronal survival critically depends on the integrity and functionality of mitochondria. A
hierarchical system of cellular surveillance mechanisms protects mitochondria against …

The historical role of mitochondria resides in converting the energy released during the
oxidation of macromolecules (carbohydrates, lipids and proteins) into adenosine tri …

Mitochondrial fission protein 1 (Fis1) was identified in yeast as being essential for
mitochondrial division or fission and subsequently determined to mediate human …

Drp1 (dynamin-related protein 1) is recruited to both mitochondrial and peroxisomal
membranes to execute fission. Fis1 and Mff are Drp1 receptor/effector proteins of …

To maintain homeostasis, every cell must constantly monitor its energy level and
appropriately adjust energy, in the form of ATP, production rates based on metabolic …

Mitochondria are essential for the maintenance of normal physiological function of tissue
cells. Mitochondria are subject to dynamic processes in order to establish a control system …