The dynamic and fluid nature of mitochondria allows for modifications in mitochondrial
shape, connectivity and cristae architecture. The precise balance of mitochondrial dynamics …

The metabolic state of stem cells is emerging as an important determinant of their fate. In the
bone marrow, haematopoietic stem cell (HSC) entry into cycle, triggered by an increase in …

The mitochondrial network constantly changes and remodels its shape to face the cellular
energy demand. In human cells, mitochondrial fusion is regulated by the large, evolutionarily …

Mitochondria are ancient organelles evolved from bacteria. Over the course of evolution, the
behavior of mitochondria inside eukaryotic cells has changed dramatically, and the …

Mitochondria contribute to cellular innate immunity against RNA viruses. Mitochondrial-
mediated innate immunity is regulated by signalling molecules that are recruited to the …

The protein optic atrophy 1 (OPA1) is a dynamin-related protein associated with the inner
mitochondrial membrane and functions in mitochondrial inner membrane fusion and cristae …

Controlled changes in mitochondrial morphology participate in cellular signaling cascades.
However, the molecular mechanisms modifying mitochondrial shape are largely unknown …

As a central hub of cellular metabolism and signaling, the mitochondrion is a crucial
organelle whose dysfunction can cause disease and whose activity is intimately connected …

Accumulating evidence suggests that changes in the metabolic signature of astrocytes
underlie their response to neuroinflammation, but how proinflammatory stimuli induce these …

Among the complex determinants of aging, mitochondrial dysfunction has been in the
spotlight for a long time. As the hub for many cellular functions, the maintenance of an …