Background: Nuclear factor‐κB (NF‐κB), a transcription factor known to modulate expression
of factors involved in inflammation, immunity, proliferation, and apoptosis, is constitutively …

Aim: This study aimed at developing antibody-functionalized gold nanoparticles (AuNPs) to
selectively target cancer cells and probing their potential radiosensitizing effects under …

Ligand binding to the EGF receptor (EGFR) triggers multiple signal-transduction processes
and promotes endocytosis of the receptor. The mechanisms of EGFR endocytosis and its …

▪ Abstract The clinical application of tyrosine kinase inhibitors for cancer treatment
represents a therapeutic breakthrough. The rationale for developing these compounds rests …

Objective To investigate the effects of ursolic acid on the proliferation and apoptosis of
human HT-29 colon cancer cells. Methods 3-(4, 5-dimethylthiazol-2-yl)-2, 5 …

Lung cancer is the most commonly diagnosed cancer in the world.“Driver” and “passenger”
mutations identified in lung cancer indicate that genetics play a major role in the …

Due to the broad importance of EGFR to tumorogenesis, targeted therapy against it has
rapidly developed into a novel paradigm for cancer treatment. Two promising classes of …

Epidermal growth factor receptor (EGFR) is a member of the erbB tyrosine kinase family
reported to be overexpressed in a variety of solid malignancies. Mutations in exons 19 to 21 …

In recent years, targeted therapy and immunotherapy have played important roles in the
treatment of patients with non-small-cell lung cancer (NSCLC). Drugs that target epidermal …

We have developed a theranostic nanoparticle, ie, cet-PEG-dexSPIONs, by conjugation of
the anti-epidermal growth factor receptor (EGFR) monoclonal antibody, cetuximab, to …