The eye has anatomical structures that function as robust static and dynamic barriers,
limiting the penetration, residence time, and bioavailability of medications administered …

Currently, the only practical way to treat type 1 and advanced insulin-dependent type 2
diabetes mellitus (T1/2DM) is the frequent subcutaneous injection of insulin, which is …

Glioblastoma multiforme (GBM) is a first primary Central Nervous System tumor with high
incidence and lethality. Its treatment is hampered by the difficulty to overcome the blood …

Breast cancer is the commonest cancer among women, with more than 2 million cases per
year and a lethality rate of 17.7%. The treatment of breast cancer still being a challenge due …

It has been seventy years since a water-soluble version of vitamin E called tocophersolan
(also known as TPGS) was produced; it was approved by USFDA in 1998 as an inactive …

According to the recent Global Cancer Statistics, female breast cancer (BC) is considered
the most commonly diagnosed cancer in 2020 surpassing lung cancer and also, the fifth …

Despite the existence of several treatment modalities and advancements in cancer research,
brain cancer is still incurable. Over-expression of nucleolin receptors on cancer cells has …

D-ɑ-tocopheryl poly (ethylene glycol) 1000 succinate (TPGS) has been extensively applied
in drug delivery systems for its amphiphilic property and inherent bioactivity. But TPGS has …

The present study aimed to engineer a nanoscale lipid-based lymphatic drug delivery
system with D-α-Tocopherol polyethylene glycol 1000 succinate to combat the lymphatic …

We evaluated the bioavailability, liver distribution, and efficacy of silymarin-D-α-tocopherol
polyethylene glycol 1000 succinate (TPGS) solid dispersion (silymarin-SD) in rats with …