The emerging novel therapeutic psilocybin produces psychedelic effects via engagement of
cerebral serotonergic targets by psilocin (active metabolite). The serotonin 2A receptor …

The discovery of ketamine as a rapid-acting antidepressant spurred significant research to
understand its underlying mechanisms of action and to identify other novel compounds that …

Drugs that modulate serotonin (5-HT) synaptic concentrations impact neurogenesis and
hippocampal (HPC)-dependent learning. The primary objective is to determine the extent to …

Psilocybin is being investigated as a treatment in adults with treatment-resistant depression
(TRD). Withdrawal from serotonergic antidepressant drugs is a common prerequisite for …

The history of serotonin research is closely related to the study of hallucinogenic drugs that
function as agonists at serotonin-2A receptors. The fundamental idea that psychotic states …

Psilocybin is the psychotropic tryptamine‐derived natural product of Psilocybe carpophores,
the so‐called “magic mushrooms”. Although its structure has been known for 60 years, the …

Microdosing psychedelics is the repeated use of small doses of, for example, lysergic acid
diethylamide (LSD) and psilocybin, typically for a few weeks. Despite the popular and …

Abstract Introduction Ayahuasca is a South American psychotropic plant tea traditionally
used in Amazonian shamanism. The tea contains the psychedelic 5-HT 2A receptor agonist …

All modern clinical studies using the classic hallucinogen lysergic acid diethylamide (LSD)
in healthy subjects or patients in the last 25 years are reviewed herein. There were five …

The development of chronic pain is a complex mechanism that is still not fully understood.
Multiple somatic and visceral afferent pain signals, when experienced over time, cause a …