Conspectus Protein–DNA interactions are important in replication, transcription, repair, as
well as epigenetic modifications of DNA, which involve methylation and demethylation of …

Labelling of nucleic acids as biologically important cellular components is a crucial
prerequisite for the visualization and understanding of biological processes. Efficient …

5-Methylcytosine (5mC) is an important type of epigenetic modification. Bisulfite sequencing
(BS-seq) has limitations, such as severe DNA degradation. Using single molecule real-time …

N 6-Methyladenine (6mA) is a naturally occurring DNA modification in both prokaryotes and
eukaryotes. Herein, we developed a deaminase-mediated sequencing (DM-seq) method for …

DNA methylation (5-methylcytosine, 5mC) is the most prevalent epigenetic modification that
is predominantly found in CG dinucleotides in mammalian genomes. In-depth investigation …

Active demethylation of 5-methylcytosine (5mC) can be realized through ten-eleven
translocation (TET) dioxygenase-mediated oxidation of 5mC to 5-hydroxymethylcytosine …

The development of new interconnections and synthetic approaches for the formation of
porous organic polymers (POPs) is a challenging endeavor. Herein, we report a facile gram …

RNA and DNA modifications occur in eukaryotes and prokaryotes, as well as in their viruses,
and serve a wide range of functions, from gene regulation to nucleic acid protection …

A rapid and sensitive electrochemical sensing platform is reported based on bimetallic gold-
platinum nanoclusters (AuPtNCs) dispersed on reduced graphene oxide (rGO) for the …

RNA molecules contain diverse modifications that play crucial roles in a wide variety of
biological processes. Adenosine-to-inosine (A-to-Ino) RNA editing is one of the most …