Essentials• The clinical value of IgM antibodies in thrombotic antiphospholipid syndrome
(APS) is debated.• By review of literature, we reconsidered the clinical value of IgM …

Antibody assessment is an essential part in the serological diagnosis of autoimmune
diseases. However, different diagnostic strategies have been proposed for the work up of …

Antiphospholipid syndrome (APS) is a systemic autoimmune condition characterised by the
presence of antiphospholipid antibodies (aPL) associated with vascular thrombosis and/or …

Background Antiphospholipid antibodies (aPL) can be detected in asymptomatic carriers
and infectious patients. The aim was to investigate whether a novel line immunoassay (LIA) …

The pathogenesis of Crohn's disease (CrD) and ulcerative colitis (UC), the two major
inflammatory bowel diseases (IBD), remains poorly understood. Autoimmunity is considered …

Dirk Reinhold was trained as a MD (1987, Moscow, Russia). Following this, he moved to
Magdeburg, Germany and specialized in Immunology. His scientific interest includes …

Inflammation in inflammatory bowel diseases (IBD) has been linked to a loss of tolerance to
self-antigens suggesting the existence of autoantibodies in specific disease phenotypes …

Purpose Anti-phospholipid antibodies (aPL) analyzed by line immunoassay (LIA) can
recognize beta 2-glycoprotein I (β 2 GPI) domain 1 (D1) epitopes depending on β 2 GPI …

The international consensus for the classification of antiphospholipid syndrome (APS)
requires clinical and laboratory criteria to be considered at an equal level for diagnosing …

Antiphospholipid syndrome (APS) is an autoimmune disease, characterized by thrombosis
and pregnancy complications with persistently elevated levels of antiphospholipid …