Over the past decade numerous publications have demonstrated how digital PCR (dPCR)
enables precise and sensitive quantification of nucleic acids in a wide range of applications …

In recent years, the introduction of new molecular techniques in experimental and clinical
settings has allowed researchers and clinicians to propose circulating-tumor DNA (ctDNA) …

The digital polymerase chain reaction (dPCR) is considered to be the third-generation
polymerase chain reaction (PCR), as it yields direct, absolute and precise measures of …

Molecular monitoring of minimal residual disease (MRD) and BCR-ABL1 kinase domain
(KD) mutation testing have a well consolidated role in the routine management of chronic …

Minimal residual disease (MRD) monitoring has proven to be one of the fundamental
independent prognostic factors for patients with acute lymphoblastic leukemia (ALL) …

The ability of droplet digital PCR (ddPCR) to accurately determine the concentrations of
amplifiable targets makes it a promising platform for measuring copy number alterations …

More than 15 years ago, imatinib entered into the clinical practice as a “magic bullet”; from
that point on, the prognosis of patients affected by chronic myeloid leukemia (CML) became …

The introduction of imatinib in 2000 opened the era of tyrosine kinase inhibitors (TKIs) for
CML therapy and has revolutionized the life expectancy of CML patients, which is now quite …

The effective and sensitive monitoring of Minimal Residual Disease or Measurable Residual
Disease (MRD) is a very important aspect in the management of patients affected by …

We describe a novel droplet digital PCR (ddPCR) assay capable of detecting genomic
alterations associated with inversion translocations. It is applied here to detection of …