Philadelphia chromosome–like (Ph-like) acute lymphoblastic leukemia (ALL) is a relatively
new entity characterized by high cytokine receptor and tyrosine kinase signaling resulting in …

Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is a recently
identified high risk disease subtype characterized by a gene expression profile similar to that …

Acute lymphoblastic leukemia (ALL) with hyperleukocytosis at diagnosis is associated with
early morbidity and mortality due to complications of leukostasis. Of 535 pediatric ALL …

Acute myeloid leukemia (AML) is a malignant disease of myeloid hematopoietic
stem/progenitor cells characterized by the abnormal proliferation of primitive and naive …

The overexpression of cytokine receptor-like factor-2 (CRLF2) identified by anti-thymic
stromal lymphopoietin receptor/TSLPR flow cytometry (FCM) has been reported as a …

Philadelphia (Ph)-like or BCR-ABL like acute lymphoblastic leukemia (ALL) is defined on the
basis of a gene expression profile that is similar to Ph-positive ALL. It comprises a wide …

Traditionally, genetic abnormalities detected by conventional karyotyping, fluorescence in
situ hybridization, and polymerase chain reaction divided childhood B-cell precursor acute …

CRISPR/Cas9 represents a valuable tool to determine protein function, but technical hurdles
limit its use in challenging settings such as cells unable to grow in vitro like primary leukemia …

Abstract Background Philadelphia chromosome (Ph)–like B‐acute lymphoblastic leukemia
(B‐ALL) is a clinically significant, high‐risk genetic subtype of B‐ALL cases. There are few …

Approximately 25% of the pediatric B-cell precursor acute lymphoblastic leukemia (BCP-
ALL) cases are genetically unclassified. More thorough elucidation of the pathobiology of …