Sperm DNA integrity is crucial for fertilization and development of healthy offspring. The
spermatozoon undergoes extensive molecular remodeling of its nucleus during later phases …

Sperm DNA damage is prevalent among infertile men and is known to influence natural
reproduction. However, the impact of sperm DNA damage on assisted reproduction …

Recurrent implantation failure refers to failure to achieve a clinical pregnancy after transfer of
at least four good-quality embryos in a minimum of three fresh or frozen cycles in a woman …

Thirty-five years ago the pioneering paper in Science (240: 1131) on the relationship
between sperm DNA integrity and pregnancy outcome was featured as the cover issue …

Intracytoplasmic sperm injection (ICSI) has become the most commonly used method of
fertilization in assisted reproductive technology. The primary reasons for its popularity stem …

Background The inability to have children affects 10% to 15% of couples worldwide. A male
factor is estimated to account for up to half of the infertility cases with between 25% to 87% of …

Increasing contamination of the environment by toxic compounds such as endocrine
disrupting chemicals (EDCs) is one of the major causes of reproductive defects in both …

Spermatogenesis is an extremely active replicative process capable of generating approxi
mately 1,000 sperm a second. The high rates of cell division inherent in this process imply …

Because germline mutations are the source of all evolutionary adaptations and heritable
diseases, characterizing their properties and the rate at which they arise across individuals …

DNA damage in the male germ line has been linked with a variety of adverse clinical
outcomes including impaired fertility, an increased incidence of miscarriage and an …