As an essential component of immunity, macrophages have key roles in mammalian host
defense, tissue homeostasis, and repair, as well as in disease pathogenesis and …

The gut is a tubular organ responsible for nutrient absorption and harbors our intestinal
microbiome. This organ is composed of a multitude of specialized cell types arranged in …

Human induced pluripotent stem cells (iPSCs) and macrophages derived from them are
increasingly popular tools for research into both infectious and degenerative diseases …

Adverse cutaneous reactions are potentially life-threatening skin side effects caused by
drugs administered into the human body. The availability of a human-specific in vitro …

Background Chromatin states and enhancers associate gene expression, cell identity and
disease. Here, we systematically delineate the acute innate immune response to endotoxin …

The generation of human macrophages from induced pluripotent stem cells (iMacs) is a
rapidly developing approach used to create disease models, screen drugs, study …

Abstract Background Type 1 diabetes (T1D) is an autoimmune disease characterized by
impaired immune tolerance to β-cell antigens and progressive destruction of insulin …

Systemic autoinflammatory diseases are a heterogeneous group of rare genetic disorders
caused by dysregulation of the innate immune system. Understanding the complex …

Upon implanting tissue-engineered heart valves (TEHVs), blood-derived macrophages are
believed to orchestrate the remodeling process. They initiate the immune response and …

Cellular reprogramming technologies have been developed with different physicochemical
factors to improve the reprogramming efficiencies of induced pluripotent stem cells (iPSCs) …